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PMID: 9326333 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes.

American journal of human genetics ·Vol. 61 ·No. 3 ·1997-09-00 ·Pages 668-77

Hasstedt SJ, Hoffman M, Leppert MF, Elbein SC

Abstract

Segregation analysis of body-mass index (BMI) supported recessive inheritance of obesity, in pedigrees ascertained through siblings with non-insulin dependent diabetes mellitus (NIDDM). BMI was estimated as 39 kg/m2 for those subjects homozygous at the inferred locus. Two-locus segregation analysis provided weak support for a second recessive locus, with BMI estimated as 32 kg/m2 for homozygotes. NIDDM prevalence was increased among those subjects presumed to be homozygous at either locus. Using both parametric and nonparametric methods, we found no evidence of linkage of obesity to any of nine candidate genes/regions, including the Prader-Willi chromosomal region (PWS), the human homologue of the mouse agouti gene (ASP), and the genes for leptin (OB), the leptin receptor (OBR/DB), the beta3-adrenergic receptor (ADRB3), lipoprotein lipase (LPL), hepatic lipase (LIPC), glycogen synthase (GYS), and tumor necrosis factor alpha (TNFA).

MeSH Terms
Adult Age of Onset Blood Glucose/analysis Body Mass Index Diabetes Mellitus/genetics Diabetes Mellitus, Type 2/blood,genetics Female Genetic Linkage Humans Insulin/blood Likelihood Functions Male Middle Aged Models, Genetic Obesity Pedigree
Chemicals
Blood Glucose Insulin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hasstedt S J
Department of Human Genetics, University of Utah, Salt Lake City 84112-5330, USA. sandy@sapporo.genetics.utah.edu
Hoffman M
Leppert M F
Elbein S C
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/515509
Email
sandy@sapporo.genetics.utah.edu
Published
1997-09-00
Pages
668-77
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1715940
Subset
IM
Grants
NIDDK NIH HHS · DK39311 · United States
NICHD NIH HHS · HD17463 · United States
NCRR NIH HHS · M01-RR00064 · United States
External Links
PubMed source DOI: 10.1086/515509 PMC Full Text View journal details
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