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PMID: 9311563 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Virulence of influenza A virus for mouse lung.

Virus genes ·Vol. 14 ·No. 3 ·1997-00-00 ·Pages 187-94

Ward AC

Abstract

The experimental infection of mouse lung with influenza A virus has proven to be an invaluable model for studying the mechanisms of viral adaptation and virulence. These investigations have identified critical roles for the haemagglutinin (HA) and matrix (M) genes of the virus in determining virulence for mouse lung. For the HA gene, the loss of glycosylation sites from the encoded polypeptide or changes which may affect the pH of HA-mediated endosome fusion have been observed following adaptation. These alterations also have the potential to impact on receptor specificity, beta inhibitor sensitivity and activation cleavage which may act in concert to account for the increased virulence of adapted strains. For the M gene, two specific changes in the M1 protein have been identified in strains adapted to, or virulent for, mouse lung. These changes are likely to affect pH-dependent association/dissociation of M1 with the viral ribonucleoprotein, and control virulence as well as growth. The role of other genes in mouse lung virulence remains unknown.

MeSH Terms
Adaptation, Biological Animals Antiviral Agents/physiology DNA-Directed DNA Polymerase/genetics Hemagglutinin Glycoproteins, Influenza Virus/genetics Influenza A virus/genetics,pathogenicity Ion Channels/genetics Lung/pathology,virology Mice Orthomyxoviridae Infections/genetics,virology Viral Matrix Proteins/genetics Virulence/genetics
Chemicals
Antiviral Agents Hemagglutinin Glycoproteins, Influenza Virus Ion Channels M-protein, influenza virus M1 protein, Influenza A virus Viral Matrix Proteins DNA-Directed DNA Polymerase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ward A C
Erasmus University Rotterdam, Institute of Hematology, The Netherlands.
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Article Info
Journal
Virus genes
Abbr.
Virus Genes
ISSN
0920-8569
DOI
10.1023/a:1007979709403
Published
1997-00-00
Pages
187-94
Language
English
Region
United States
NLM ID
8803967
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1007979709403 View journal details
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