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PMID: 929187 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Physical structure of the replication origin of bacteriophage lambda.

Science (New York, N.Y.) ·Vol. 198 ·No. 4321 ·1977-12-09 ·Pages 1051-6

Denniston-Thompson K, Moore DD, Kruger KE, Furth ME, Blattner FR

Abstract

The nucleotide sequence of part of the replication region of wild-type bacteriophage lambda and of four mutants defective in the origin of DNA replication (ori-) has been determined. Three of the ori- mutations are small deletions, and one is a transversion. The sequence of the origin region, defined by these mutations, contains a number of unusual features.

MeSH Terms

Base Sequence Coliphages/genetics DNA Replication DNA Restriction Enzymes DNA, Recombinant/genetics DNA, Viral/biosynthesis Genes Genes, Regulator Genes, Viral Mutation Plasmids RNA, Viral/biosynthesis Virus Replication

Chemicals

DNA, Recombinant DNA, Viral RNA, Viral DNA Restriction Enzymes

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Denniston-Thompson K

Moore D D

Kruger K E

Furth M E

Blattner F R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.929187

Published

1977-12-09

Pages

1051-6

Language

English

Region

United States

NLM ID

0404511

Subset

Databases

GENBANK

J02459, M17233

External Links

PubMed source DOI: 10.1126/science.929187 View journal details

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Physical structure of the replication origin of bacteriophage lambda.

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