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PMID: 9287189 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis.

Current opinion in immunology ·Vol. 9 ·No. 4 ·1997-08-00 ·Pages 563-7

Grouard G, Clark EA

Abstract

Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.

MeSH Terms

Antigen Presentation Dendritic Cells/immunology,virology HIV/physiology HIV Antigens/immunology HIV Infections/etiology,immunology Humans Lymph Nodes/immunology,ultrastructure Mucous Membrane/immunology,pathology RNA, Messenger/metabolism RNA, Viral/metabolism Receptors, Virus/physiology Virion/physiology Virus Replication

Chemicals

HIV Antigens RNA, Messenger RNA, Viral Receptors, Virus

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Grouard G

Regional Primate Research Center, Department of Microbiology, University of Washington Medical Center, Seattle, WA 98195, USA.

Clark E A

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/s0952-7915(97)80111-2

Published

1997-08-00

Pages

563-7

Language

English

Region

England

NLM ID

8900118

Subset

Grants

NIGMS NIH HHS · GM37905 · United States

NCRR NIH HHS · RR00166 · United States

Corrections

CommentIn

PMID: 9287181

External Links

PubMed source DOI: 10.1016/s0952-7915(97)80111-2 View journal details

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Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis.

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