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PMID: 9284370 Published · ppublish English Journal Article Review

Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.

Emerging infectious diseases ·Vol. 3 ·No. 3 ·1997-00-00 ·Pages 261-71

McNicholl JM, Smith DK, Qari SH, Hodge T

Abstract

Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new hope for the prevention and treatment of HIV infection. One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. We also examine the effect of this discovery on medical and public health practices.

MeSH Terms
Adult Alleles Amino Acid Sequence Base Sequence Child DNA/genetics Genetics, Population HIV/pathogenicity HIV Infections/etiology,genetics,immunology Humans Molecular Sequence Data Molecular Structure Mutation Polymorphism, Genetic Receptors, CCR5 Receptors, Cytokine/chemistry,genetics Receptors, HIV/chemistry,genetics Sequence Deletion
Chemicals
Receptors, CCR5 Receptors, Cytokine Receptors, HIV DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
McNicholl J M
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. jkm7@cdc.gov
Smith D K
Qari S H
Hodge T
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Article Info
Journal
Emerging infectious diseases
Abbr.
Emerg Infect Dis
ISSN
1080-6040
DOI
10.3201/eid0303.970302
Email
jkm7@cdc.gov
Published
1997-00-00
Pages
261-71
Language
English
Region
United States
NLM ID
9508155
PMCID
PMC2627644
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.3201/eid0303.970302 PMC Full Text View journal details
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