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PMID: 9282752 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Analysis of cis-acting sequence and structural elements required for antitermination of the Bacillus subtilis tyrS gene.

Molecular microbiology ·Vol. 25 ·No. 2 ·1997-07-00 ·Pages 411-21

Rollins SM, Grundy FJ, Henkin TM

Abstract

The Bacillus subtilis tyrS gene belongs to the T box family of aminoacyl-tRNA synthetase and amino acid biosynthesis genes, which are regulated by a common mechanism of transcriptional antitermination. Each gene is induced by specific amino acid limitation; the uncharged cognate tRNA is the effector inducing transcription of the full-length message. The leader regions of the genes in this family share a number of conserved primary sequence and secondary structural elements, the functions of which are unknown. In this study, we examine these regions and report the effects of mutations in several of these elements. In addition, two alternative basepairings in the F box region were found to be necessary for tyrS antitermination.

MeSH Terms
Bacillus subtilis/genetics Base Sequence Gene Expression Regulation, Bacterial Genes, Bacterial Molecular Sequence Data TATA Box Tyrosine-tRNA Ligase/genetics
Chemicals
Tyrosine-tRNA Ligase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rollins S M
Department of Microbiology, Ohio State University, Columbus 43210, USA.
Grundy F J
Henkin T M
Article Info
Journal
Molecular microbiology
Abbr.
Mol Microbiol
ISSN
0950-382X
DOI
10.1046/j.1365-2958.1997.4851839.x
Published
1997-07-00
Pages
411-21
Language
English
Region
England
NLM ID
8712028
Subset
IM
Grants
NIGMS NIH HHS · R01 GM047823 · United States
NIGMS NIH HHS · GM47823 · United States
Databases
GENBANK
D00496, D26185, L08854, L14580, M14742, M16318, M24068, M36594, M77668, M87009, M87483, M88581, M90760, U41072, X04193, X52480, X53057, X54740, X66121, X77239, X89438, Z21501
External Links
PubMed source DOI: 10.1046/j.1365-2958.1997.4851839.x View journal details
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