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PMID: 9281353 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase.

Experimental cell research ·Vol. 235 ·No. 1 ·1997-08-25 ·Pages 62-70

Zhang L, Martelli ML, Battaglia C, Trapasso F, Tramontano D, Viglietto G, Porcellini A, Santoro M, Fusco A

Abstract

We have isolated a rat thyroid cDNA encoding a novel rat receptor-type tyrosine phosphatase protein. This gene, on the basis of its homology to another tyrosine phosphatase, the recently isolated human DEP-1/HPTPeta, has been named r-PTPeta. In rat thyroid cells the r-PTPeta gene acts as a differentiation marker. Indeed, the block of thyroid cell differentiation induced by viral and cellular oncogenes is associated with the inhibition or marked reduction of the expression of this gene, and its expression is positively regulated by thyrotropin, the physiological stimulator of thyroid cell growth.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cell Differentiation Cell Line Cell Transformation, Neoplastic Codon DNA Primers DNA, Complementary Gene Expression Regulation, Enzymologic/drug effects Humans Male Molecular Sequence Data Oncogenes Organ Specificity Polymerase Chain Reaction Protein Tyrosine Phosphatases/biosynthesis,chemistry,isolation & purification Rats Rats, Inbred F344 Receptor-Like Protein Tyrosine Phosphatases, Class 3 Restriction Mapping Sequence Homology, Amino Acid Thyroid Gland/cytology,enzymology Thyrotropin/pharmacology Transcription, Genetic

Chemicals

Codon DNA Primers DNA, Complementary Thyrotropin PTPRJ protein, human Protein Tyrosine Phosphatases Receptor-Like Protein Tyrosine Phosphatases, Class 3

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Zhang L

Facoltà di Medicina e Chirurgia di Catanzaro, Università degli Studi di Reggio Calabria, via Tommaso Campanella 5, Catanzaro, 88100, Italy.

Martelli M L

Battaglia C

Trapasso F

Tramontano D

Viglietto G

Porcellini A

Santoro M

Fusco A

Article Info

Journal

Experimental cell research

Abbr.

Exp Cell Res

ISSN

0014-4827

DOI

10.1006/excr.1997.3659

Published

1997-08-25

Pages

62-70

Language

English

Region

United States

NLM ID

0373226

Subset

External Links

PubMed source DOI: 10.1006/excr.1997.3659 View journal details

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Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase.

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