Home LiteratureArticle Details
PMID: 9276721 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor.

The Journal of clinical investigation ·Vol. 100 ·No. 5 ·1997-09-01 ·Pages 1047-58

Wolf G, Ziyadeh FN, Thaiss F, Tomaszewski J, Caron RJ, Wenzel U, Zahner G, Helmchen U, Stahl RA

Abstract

Glomerular influx of monocytes/macrophages (M/M) occurs in many immune- and non-immune-mediated renal diseases. The mechanisms targeting M/M into the glomerulus are incompletely understood, but may involve stimulated expression of chemokines. We investigated whether angiotensin II (ANG II) induces the chemokine RANTES in cultured glomerular endothelial cells of the rat and in vivo. ANG II stimulated mRNA and protein expression of RANTES in cultured glomerular endothelial cells. The ANG II-induced RANTES protein was chemotactic for human monocytes. Surprisingly, the ANG II-stimulated RANTES expression was transduced by AT2 receptors because the AT2 receptor antagonists PD 123177 and CGP-42112A, but not an AT1 receptor blocker, abolished the induced RANTES synthesis. Intraperitoneal infusion of ANG II (500 ng/h) into naive rats for 4 d significantly stimulated glomerular RANTES mRNA and protein expression compared with solvent-infused controls. Immunohistochemistry revealed induction of RANTES protein mainly in glomerular endothelial cells and small capillaries. Moreover, ANG II- infused animals exhibited an increase in glomerular ED-1- positive cells compared with controls. Oral treatment with PD 123177 (50 mg/liter drinking water) attenuated the glomerular M/M influx without normalizing the slightly elevated systolic blood pressure caused by ANG II infusion, suggesting that the effects on blood pressure and RANTES induction can be separated. We conclude that the vasoactive peptide ANG II may play an important role in glomerular chemotaxis of M/M through local induction of the chemokine RANTES. The observation that the ANG II- mediated induction of RANTES is transduced by AT2 receptors may influence the decision as to which substances might be used for the therapeutic interference with the activity of the renin-angiotensin system.

MeSH Terms
Angiotensin II/pharmacology Animals Cells, Cultured Chemokine CCL5/biosynthesis Endothelium/metabolism Kidney Glomerulus/drug effects,metabolism Male Rats Rats, Sprague-Dawley Receptors, Angiotensin/classification,physiology
Chemicals
Chemokine CCL5 Receptors, Angiotensin Angiotensin II
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Wolf G
Department of Medicine, University of Hamburg, D-20246 Hamburg, Germany.
Ziyadeh F N
Thaiss F
Tomaszewski J
Caron R J
Wenzel U
Zahner G
Helmchen U
Stahl R A
References (57)
57 references, click to expand
  1. Distribution of angiotensin II receptor subtypes in rat and human kidney.
    Am J Physiol. 1992 Feb;262(2 Pt 2):F236-40 PMID: 1539685
  2. Regulation of transendothelial neutrophil migration by endogenous interleukin-8.
    Science. 1991 Oct 4;254(5028):99-102 PMID: 1718038
  3. Renal injury from angiotensin II-mediated hypertension.
    Hypertension. 1992 May;19(5):464-74 PMID: 1568765
  4. Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes.
    Kidney Int. 1992 Jan;41(1):220-5 PMID: 1375672
  5. Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration.
    Immunol Today. 1992 Aug;13(8):291-4 PMID: 1510812
  6. Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass.
    J Clin Invest. 1992 Sep;90(3):766-71 PMID: 1522231
  7. In vitro autoradiography reveals predominantly AT1 angiotensin II receptors in rat kidney.
    Ren Physiol Biochem. 1992 Sep-Oct;15(5):231-9 PMID: 1279763
  8. Angiotensin II as a renal growth factor.
    J Am Soc Nephrol. 1993 Mar;3(9):1531-40 PMID: 8507808
  9. Angiotensin II receptor subtypes in the kidney.
    J Am Soc Nephrol. 1993 Apr;3(10):1643-52 PMID: 8318680
  10. Angiotensin III is a new chemoattractant for polymorphonuclear leukocytes.
    Biochem Biophys Res Commun. 1993 Jun 30;193(3):1038-43 PMID: 8323529
  11. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.
    J Clin Invest. 1993 Sep;92(3):1366-72 PMID: 7690779
  12. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.
    J Biol Chem. 1993 Nov 25;268(33):24539-42 PMID: 8227010
  13. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.
    J Biol Chem. 1993 Nov 25;268(33):24543-6 PMID: 8227011
  14. TNF alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells.
    Kidney Int. 1993 Oct;44(4):795-804 PMID: 7505037
  15. Increased expression of monocyte chemoattractant protein-1 in anti-thymocyte antibody-induced glomerulonephritis.
    Kidney Int. 1993 Nov;44(5):1036-47 PMID: 8264133
  16. RANTES chemokine expression in cell-mediated transplant rejection of the kidney.
    Lancet. 1994 Jan 22;343(8891):209-11 PMID: 7507196
  17. Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor, AT2.
    Biochem Biophys Res Commun. 1994 Jan 14;198(1):60-6 PMID: 7507323
  18. Macrophages in renal injury.
    Kidney Int Suppl. 1994 Feb;45:S79-82 PMID: 8158904
  19. Effects of delayed treatment with enalapril and/or lovastatin on the progression of glomerulosclerosis in 5/6 nephrectomized rats.
    Nephrol Dial Transplant. 1993;8(12):1338-43 PMID: 8159302
  20. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis.
    Kidney Int. 1994 Feb;45(2):515-24 PMID: 8164440
  21. Macrophages in acute glomerular inflammation.
    Kidney Int. 1994 Apr;45(4):945-52 PMID: 8007597
  22. Activation of human peripheral monocytes by angiotensin II.
    FEBS Lett. 1994 Jun 27;347(2-3):178-80 PMID: 7518396
  23. Angiotensin II stimulates protein tyrosine phosphatase activity through a G-protein independent mechanism.
    Receptors Channels. 1994;2(2):89-98 PMID: 7953293
  24. Macrophages and renal disease.
    Lab Invest. 1994 Oct;71(4):456-64 PMID: 7967502
  25. Angiotensin II type II receptor. Does it have a role in the normal or diseased kidney?
    Nephrol Dial Transplant. 1994;9(10):1364-5 PMID: 7816244
  26. Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-gamma plus TNF-alpha and inhibition by IL-4 and IL-13.
    J Immunol. 1995 Feb 15;154(4):1870-8 PMID: 7530744
  27. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.
    J Clin Invest. 1995 Feb;95(2):651-7 PMID: 7860748
  28. Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.
    J Clin Invest. 1995 Mar;95(3):1394-7 PMID: 7883985
  29. Suppressive role of endogenous endothelial monocyte chemoattractant protein-1 on monocyte transendothelial migration in vitro.
    Arterioscler Thromb Vasc Biol. 1995 May;15(5):629-36 PMID: 7749876
  30. Cellular events in the evolution of experimental diabetic nephropathy.
    Kidney Int. 1995 Mar;47(3):935-44 PMID: 7752595
  31. Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region.
    Biochim Biophys Acta. 1995 Jun 9;1262(2-3):155-8 PMID: 7599191
  32. Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy.
    Am J Kidney Dis. 1995 Jul;26(1):141-6 PMID: 7611245
  33. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney.
    J Clin Invest. 1995 Aug;96(2):953-64 PMID: 7635988
  34. Thrombin regulates expression of monocyte chemoattractant protein-1 in vascular smooth muscle cells.
    Circ Res. 1995 Sep;77(3):503-9 PMID: 7641321
  35. The role of chemokines in the initiation and progression of renal disease.
    Kidney Int Suppl. 1995 Jun;49:S44-7 PMID: 7674593
  36. Angiotensin II and glomerulonephritis.
    J Hypertens. 1995 May;13(5):487-93 PMID: 7561004
  37. Angiotensin II-mediated renal injury.
    Miner Electrolyte Metab. 1995;21(4-5):328-35 PMID: 7565481
  38. Chemokines and renal disease.
    Am J Kidney Dis. 1995 Dec;26(6):982-94 PMID: 7503075
  39. Angiotensin II is mitogenic for cultured rat glomerular endothelial cells.
    Hypertension. 1996 Apr;27(4):897-905 PMID: 8613266
  40. Angiotensin-converting enzyme inhibition in experimental in-situ immune complex glomerulonephritis: influence on renal function, proteinuria, and morphology.
    Nephrol Dial Transplant. 1996 Jan;11(1):40-6 PMID: 8649651
  41. Transforming growth factor beta mediates the angiotensin-II-induced stimulation of collagen type IV synthesis in cultured murine proximal tubular cells.
    Nephrol Dial Transplant. 1996 Feb;11(2):263-9 PMID: 8671777
  42. RANTES chemokine expression in diseased and normal human tissues.
    Cytokine. 1996 Jan;8(1):89-98 PMID: 8742071
  43. Vasoactive hormones and renal sclerosis.
    Kidney Int. 1996 Feb;49(2):578-97 PMID: 8821847
  44. Angiotensin II stimulation of prostaglandin E2 and 6-keto-F1 alpha formation by isolated human glomeruli.
    Kidney Int. 1984 Jul;26(1):30-4 PMID: 6592393
  45. Angiotensin II stimulation of granuloma macrophage phagocytosis and actin polymerization in murine schistosomiasis mansoni.
    Cell Immunol. 1984 Nov;89(1):46-54 PMID: 6541527
  46. Secretory products of macrophages.
    J Clin Invest. 1987 Feb;79(2):319-26 PMID: 3543052
  47. Rapid purification of human peripheral blood monocytes by centrifugation through Ficoll-Hypaque and Sepracell-MN.
    J Immunol Methods. 1988 Jun 13;110(2):203-7 PMID: 2837516
  48. Effects of dietary interventions on glomerular pathophysiology.
    Am J Physiol. 1990 Jan;258(1 Pt 2):F1-8 PMID: 2405707
  49. Quantitation of protein.
    Methods Enzymol. 1990;182:50-68 PMID: 2314256
  50. Effect of dietary protein on rat renin and angiotensinogen gene expression.
    J Clin Invest. 1990 Apr;85(4):1144-9 PMID: 2180982
  51. Components of the angiotensin system cause release of a neutrophil chemoattractant from cultured bovine and human endothelial cells.
    Eur Heart J. 1990 Apr;11 Suppl B:100-7 PMID: 2194806
  52. Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Amelioration by angiotensin I converting enzyme inhibition.
    Am J Pathol. 1990 Dec;137(6):1323-32 PMID: 2260622
  53. A multiwell cell settling and adherence chamber for morphology and differential counting.
    Biotechniques. 1990 Dec;9(6):684, 686, 688-9 PMID: 1702974
  54. The role of the macrophage in glomerular injury.
    Semin Nephrol. 1991 May;11(3):268-75 PMID: 2057641
  55. Biology of the RANTES/SIS cytokine family.
    Cytokine. 1991 May;3(3):165-83 PMID: 1715772
  56. Properties of the novel proinflammatory supergene "intercrine" cytokine family.
    Annu Rev Immunol. 1991;9:617-48 PMID: 1910690
  57. Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model.
    Kidney Int. 1992 Feb;41(2):297-309 PMID: 1313122
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI119615
Published
1997-09-01
Pages
1047-58
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC508279
Subset
IM
Grants
NIDDK NIH HHS · DK-07006 · United States
NIDDK NIH HHS · DK-44513 · United States
NIDDK NIH HHS · DK-45191 · United States
External Links
PubMed source DOI: 10.1172/JCI119615 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2