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PMID: 9266631 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Immunopathology of hepatitis C.

Springer seminars in immunopathology ·Vol. 19 ·No. 1 ·1997-00-00 ·Pages 57-68

Chang KM, Rehermann B, Chisari FV

Abstract

Hepatitis C virus (HCV) infection becomes persistent in the majority of instances in the face of a humoral and cellular immune response, and persistent HCV infection is associated with chronic hepatitis. In particular, cytotoxic T lymphocytes (CTL), crucial in the eradication of virus-infected cells, have been observed in the liver and the peripheral blood of chronically infected patients, suggesting that CTL cannot completely eliminate the virus, and may contribute to chronic liver injury. In this review, the potential host and the viral factors involved in the pathogenesis of chronic HCV infection will be discussed with emphasis on the HLA-A2 restricted peripheral blood CTL response and its relationship to liver disease and viral load.

MeSH Terms
Amino Acid Sequence Epitopes/genetics HLA-A2 Antigen/metabolism Hepacivirus/genetics,immunology,pathogenicity Hepatitis C/etiology,immunology,pathology Hepatitis C Antigens/genetics Hepatitis, Chronic/etiology,immunology,pathology Humans Immune Tolerance T-Lymphocytes, Cytotoxic/immunology
Chemicals
Epitopes HLA-A2 Antigen Hepatitis C Antigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chang K M
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.
Rehermann B
Chisari F V
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Article Info
Journal
Springer seminars in immunopathology
Abbr.
Springer Semin Immunopathol
ISSN
0344-4325
DOI
10.1007/BF00945025
Published
1997-00-00
Pages
57-68
Language
English
Region
Germany
NLM ID
7910384
Subset
IM
Grants
NIAID NIH HHS · AI 20001 · United States
NCRR NIH HHS · RR-00833 · United States
NIDDK NIH HHS · T32DKO7202 · United States
External Links
PubMed source DOI: 10.1007/BF00945025
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