DNA repair: RAD alert.

Current biology : CB ·Vol. 7 ·No. 8 ·1997-08-01 ·Pages R492-5

Ivanov EL, Haber JE

Abstract

Mammalian homologues of two important yeast genes involved in DNA double-strand break repair and recombination, RAD51 and RAD54, have been isolated. Knock-out mutations of the genes in mice reveal both reassuring similarities to, and surprising differences from, the analogous mutant phenotypes in yeast.

MeSH Terms

Animals DNA Helicases DNA Repair/genetics DNA Repair Enzymes DNA-Binding Proteins/genetics,metabolism Fungal Proteins/genetics,metabolism Genes, Fungal Humans Mice Mice, Knockout Mutation Phenotype Rad51 Recombinase Recombination, Genetic Saccharomyces cerevisiae/genetics,metabolism Saccharomyces cerevisiae Proteins

Chemicals

DNA-Binding Proteins Fungal Proteins Saccharomyces cerevisiae Proteins RAD51 protein, S cerevisiae RAD51 protein, human Rad51 Recombinase Rad51 protein, mouse RAD54 protein, S cerevisiae DNA Helicases DNA Repair Enzymes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ivanov E L

Transkaryotic Therapies Inc, Cambridge, Massachusetts 02139, USA.

Haber J E

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(06)00246-6

Published

1997-08-01

Pages

R492-5

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(06)00246-6 View journal details

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