Home LiteratureArticle Details

PMID: 9253405 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.

Nature structural biology ·Vol. 4 ·No. 8 ·1997-08-00 ·Pages 605-8

Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE

Abstract

The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

MeSH Terms

Amino Acid Sequence DNA/chemistry DNA-Binding Proteins/chemistry Lysine/chemistry Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Peptide Fragments/chemistry Protein Conformation Transcription Factor TFIIIA Transcription Factors/chemistry Zinc Fingers

Chemicals

DNA-Binding Proteins Peptide Fragments Transcription Factor TFIIIA Transcription Factors DNA Lysine

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Foster M P

Wuttke D S

Radhakrishnan I

Case D A

Gottesfeld J M

Wright P E

Article Info

Journal

Nature structural biology

Abbr.

Nat Struct Biol

ISSN

1072-8368

DOI

10.1038/nsb0897-605

Published

1997-08-00

Pages

605-8

Language

English

Region

United States

NLM ID

9421566

Subset

External Links

PubMed source DOI: 10.1038/nsb0897-605

Analysis Services

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.

Contact

WeChat Official Account