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PMID: 9246034 Published · ppublish English Journal Article

Gain of chromosome 20 is a frequent aberration in liver metastasis of colorectal cancers.

Digestive diseases and sciences ·Vol. 42 ·No. 7 ·1997-07-00 ·Pages 1388-93

Nanashima A, Yamaguchi H, Yasutake T, Sawai T, Kusano H, Tagawa Y, Nakagoe T, Ayabe H

Abstract

To investigate the characteristics of the numerical chromosome aberrations in liver metastasis of colorectal cancers, fluorescence in situ hybridization (FISH) for chromosomes 8, 18, 14/22, and 20 was performed in 18 specimens of primary regions and 18 of metastatic regions in liver metastasis of colorectal cancers compared with 15 of non-liver metastatic cancers. Among these numerical aberrations, the gain of chromosome 20, especially copy numbers exceeding three, was frequently observed in primary and metastatic cancers. Among these numerical aberrations, the gain of chromosome 20, especially copy numbers exceeding three, was frequently observed in primary and metastatic regions of liver metastasis groups compared with that of the non-liver metastasis group (P < 0.05). The incidences of gain of chromosome 20 in both regions of the liver metastasis group were higher than that of the non-liver metastasis group (P < 0.05). The gain of chromosome 20 is a frequent aberration in primary and metastatic regions in patients with liver metastatic colorectal cancers and may be available as a genetic marker for the diagnosis or prediction of liver metastasis.

MeSH Terms
Case-Control Studies Chromosome Aberrations Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 8 Colorectal Neoplasms/genetics,pathology Genetic Markers Humans In Situ Hybridization, Fluorescence Liver Neoplasms/genetics,secondary
Chemicals
Genetic Markers
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Nanashima A
First Department of Surgery, Nagasaki University School of Medicine, Japan.
Yamaguchi H
Yasutake T
Sawai T
Kusano H
Tagawa Y
Nakagoe T
Ayabe H
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Article Info
Journal
Digestive diseases and sciences
Abbr.
Dig Dis Sci
ISSN
0163-2116
DOI
10.1023/a:1018885803931
Published
1997-07-00
Pages
1388-93
Language
English
Region
United States
NLM ID
7902782
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1018885803931 View journal details
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