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PMID: 9230394 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Coinfection with Bartonella clarridgeiae and Bartonella henselae and with different Bartonella henselae strains in domestic cats.

Journal of clinical microbiology ·Vol. 35 ·No. 8 ·1997-08-00 ·Pages 2120-3

Gurfield AN, Boulouis HJ, Chomel BB, Heller R, Kasten RW, Yamamoto K, Piemont Y

Abstract

Bartonella clarridgeiae and several strains of Bartonella henselae, the agent of cat scratch disease, with variations in the 16S rRNA gene have been found to infect the blood of cats. An epidemiologic study of Bartonella infection in domestic French cats revealed that of 436 cats sampled, 5 cats (1.1%) were coinfected with B. henselae and B. clarridgeiae and 2 cats (0.5%) were coinfected with two strains of B. henselae with variations in the 16S rRNA gene, B. henselae type I and type II. In an indirect immunofluorescence assay, coinfected cats tested positive for both Bartonella species at titers of > or = 128. Identification of the colonies was achieved by preformed enzyme analysis, PCR-restriction fragment length polymorphism analysis of the citrate synthase gene, and 16S rRNA gene sequencing. Colony size differences in mixed culture allowed differentiation of the Bartonella species. The coinfection of cats with two Bartonella species or variants of the same species raises concern about the possibility of dual infection in humans. The development of a polyvalent vaccine targeted against the most pathogenic or invasive strains may be a means of protecting cats and man from infection.

MeSH Terms
Animals Bartonella/isolation & purification Bartonella Infections/epidemiology,veterinary Bartonella henselae/isolation & purification Cat Diseases/epidemiology,microbiology Cat-Scratch Disease/microbiology Cats Female Male Polymerase Chain Reaction Polymorphism, Restriction Fragment Length RNA, Bacterial/genetics RNA, Ribosomal, 16S/genetics
Chemicals
RNA, Bacterial RNA, Ribosomal, 16S
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Gurfield A N
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, 95616, USA.
Boulouis H J
Chomel B B
Heller R
Kasten R W
Yamamoto K
Piemont Y
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.35.8.2120-2123.1997
Published
1997-08-00
Pages
2120-3
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC229915
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.35.8.2120-2123.1997 PMC Full Text View journal details
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