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PMID: 9230312 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

Cell ·Vol. 90 ·No. 1 ·1997-07-11 ·Pages 169-80

Ericson J, Rashbass P, Schedl A, Brenner-Morton S, Kawakami A, van Heyningen V, Jessell TM, Briscoe J

Abstract

Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.

MeSH Terms

Animals Chick Embryo DNA-Binding Proteins/biosynthesis,physiology Embryonic Induction Eye Proteins Hedgehog Proteins Homeobox Protein Nkx-2.2 Homeodomain Proteins/biosynthesis Interneurons/classification,cytology,physiology Motor Neurons/classification,cytology,physiology Nervous System/cytology,embryology Neurons/cytology,physiology Organ Culture Techniques PAX6 Transcription Factor Paired Box Transcription Factors Proteins/physiology Repressor Proteins Rhombencephalon/cytology,embryology Signal Transduction Spinal Cord/cytology,embryology Stem Cells/cytology,physiology Trans-Activators Transcription Factors/biosynthesis,physiology Zebrafish Proteins

Chemicals

DNA-Binding Proteins Eye Proteins Hedgehog Proteins Homeobox Protein Nkx-2.2 Homeodomain Proteins PAX6 Transcription Factor Paired Box Transcription Factors Proteins Repressor Proteins Trans-Activators Transcription Factors Zebrafish Proteins nkx2.2b protein, zebrafish

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Ericson J

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.

Rashbass P

Schedl A

Brenner-Morton S

Kawakami A

van Heyningen V

Jessell T M

Briscoe J

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(00)80323-2

Published

1997-07-11

Pages

169-80

Language

English

Region

United States

NLM ID

0413066

Subset

Grants

Medical Research Council · MC_U127527199 · United Kingdom

External Links

PubMed source DOI: 10.1016/s0092-8674(00)80323-2 View journal details

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Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

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