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PMID: 9223463 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Functional management of an antiviral cytotoxic T-cell response.

Journal of virology ·Vol. 71 ·No. 8 ·1997-08-00 ·Pages 5764-8

Bachmann MF, Speiser DE, Ohashi PS

Abstract

Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Lymphocytic choriomeningitis virus/immunology Mice Mice, Inbred C57BL Mutation T-Lymphocytes, Cytotoxic/physiology
Chemicals
Antibodies, Monoclonal
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bachmann M F
Department of Medical Biophysics, Ontario Cancer Institute, Toronto, Canada. bachmann@oci.utoronto.ca
Speiser D E
Ohashi P S
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.71.8.5764-5768.1997
Email
bachmann@oci.utoronto.ca
Published
1997-08-00
Pages
5764-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC191829
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.71.8.5764-5768.1997 PMC Full Text View journal details
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