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PMID: 9215677 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.

Human molecular genetics ·Vol. 6 ·No. 7 ·1997-07-00 ·Pages 1069-77

Jay P, Sahly I, Gozé C, Taviaux S, Poulat F, Couly G, Abitbol M, Berta P

Abstract

SOX (SRY box-containing) genes share a particular DNA-binding domain, called HMG, with the mammalian testis-determining gene SRY Several SOX genes have already been shown to be transcription factors involved in the decision of important cell fates during development. Here we report the cloning of a new human member of the SOX gene family, SOX22. The corresponding protein contains several domains that are also present in other paralogous SOX proteins. The SOX22 gene maps to chromosome 20 on band p13 and does not appear to be clustered with any other SOX gene mapped to date. SOX22 mRNA is expressed in various fetal and adult organs and tissues, suggesting that this gene plays roles in both differentiation and maintenance of several cell types.

MeSH Terms

Age Factors Amino Acid Sequence Binding Sites Blotting, Northern Brain/embryology,metabolism Chromosome Mapping Chromosomes, Human, Pair 20 Cloning, Molecular Conserved Sequence DNA-Binding Proteins/genetics,metabolism Embryo, Mammalian/physiology Female Gene Expression Regulation, Developmental High Mobility Group Proteins/genetics Humans In Situ Hybridization Molecular Sequence Data Nerve Tissue Proteins/genetics,metabolism Nervous System/embryology Nervous System Physiological Phenomena Pregnancy SOXC Transcription Factors Sequence Analysis Sequence Homology, Amino Acid Tissue Distribution Trans-Activators/genetics

Chemicals

DNA-Binding Proteins High Mobility Group Proteins Nerve Tissue Proteins SOX11 protein, human SOX12 protein, human SOX4 protein, human SOXC Transcription Factors Trans-Activators

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Jay P

Centre de Recherches de Biochimie Macromoléculaire, CNRS ERS155, Montpellier, France.

Sahly I

Gozé C

Taviaux S

Poulat F

Couly G

Abitbol M

Berta P

Article Info

Journal

Human molecular genetics

Abbr.

Hum Mol Genet

ISSN

0964-6906

DOI

10.1093/hmg/6.7.1069

Published

1997-07-00

Pages

1069-77

Language

English

Region

England

NLM ID

9208958

Subset

Databases

GENBANK

U35612

External Links

PubMed source DOI: 10.1093/hmg/6.7.1069 View journal details

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SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.

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