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PMID: 921545 Published · ppublish English Comparative Study Journal Article

Enchancement of leukemogenesis in mice after prolonged administration of anti-interferon or normal rabbit globulin.

Archives of virology ·Vol. 55 ·No. 1-2 ·1977-00-00 ·Pages 67-75

Inglot AD, Chudzio T

Abstract

The prolonged adminstration of rabbit anti-mouse L cell interferon globulin had a marked potentiating effect on Rauscher Murine Leukemia Virus (MuLV-R) infection in BALB/c mice, as shown by spleen size. Normal rabbit globulin had a lesser, but still significant, augmenting effect on splenic enlargement. It was possible to discriminate quantitatively between the non-specific enhancement of splenomegaly in MuLV-R infected mice due to antigenic stimulation with normal rabbit globulin and the effects due to elimination of endogenous interferon by specific antibodies. The difference in the spleen-enlarging activity between the anti-interferon IgG and normal rabbit IgG was found to be maximal 3-4 weeks after infection when potent, diluted anti-interferon IgG (58 microgram protein per dose) was used. It would appear that the endogenous interferon, even prodcued in undetectable amounts, plays an essential role in controlling infection with an oncogenic virus.

MeSH Terms
Animals Female Immunoglobulin G/administration & dosage Interferons/immunology Leukemia, Experimental/blood,immunology Male Mice Mice, Inbred BALB C Rabbits Rauscher Virus Splenomegaly/etiology
Chemicals
Immunoglobulin G Interferons
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Inglot A D
Chudzio T
References (18)
18 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01314480
Published
1977-00-00
Pages
67-75
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01314480 View journal details
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