Analysis of the fusion protein gene of the porcine rubulavirus LPMV: comparative analysis of paramyxovirus F proteins.
Complementary DNA clones representing the fusion (F) protein gene of the porcine rubulavirus LPMV were isolated and sequenced. The F gene was found to be 1,845 nucleotides long containing one long open reading frame capable of encoding a protein of 541 amino acids. The cleavage motif for F0 into F1 and F2 is His-Arg-Lys-Lys-Arg. A sequence comparison and a phylogenetic analysis was performed in order to identify possible functional domains of paramyxovirus fusion proteins and also to classify the porcine rubulavirus. The F gene of LPMV is most closely related to the human mumps virus and simian virus type 5 F genes, and is therefore classified into the rubulavirus genus. A coding region for a small hydrophobic protein was however not found between the F and hemagglutinin-neuraminidase (HN) genes as previously found in both SV5 and mumps.
23 references, click to expand
-
mRNA sequence and deduced amino acid sequence of the mumps virus small hydrophobic protein gene.J Virol. 1989 Mar;63(3):1413-5 PMID: 2915385
-
Functional interactions between the fusion protein and hemagglutinin-neuraminidase of human parainfluenza viruses.J Virol. 1992 Mar;66(3):1528-34 PMID: 1310764
-
Fusion properties of cells persistently infected with human parainfluenza virus type 3: participation of hemagglutinin-neuraminidase in membrane fusion.J Virol. 1991 Jun;65(6):2773-7 PMID: 1851852
-
Encephalomyelitis, reproductive failure and corneal opacity (blue eye) in pigs, associated with a paramyxovirus infection.Vet Rec. 1988 Jan 2;122(1):6-10 PMID: 3363809
-
Characterization of a paramyxovirus isolated from the brain of a piglet in Mexico.Arch Virol. 1986;91(3-4):221-31 PMID: 3778211
-
The molecular biology of the porcine paramyxovirus LPMV.Vet Microbiol. 1992 Nov;33(1-4):263-73 PMID: 1481359
-
Identification of the porcine paramyxovirus LPMV matrix protein gene: comparative sequence analysis with other paramyxoviruses.J Gen Virol. 1991 May;72 ( Pt 5):1045-50 PMID: 2033388
-
The P gene of the porcine paramyxovirus LPMV encodes three possible polypeptides P, V and C: the P protein mRNA is edited.J Gen Virol. 1992 May;73 ( Pt 5):1195-200 PMID: 1588322
-
Identification and predicted sequence of a previously unrecognized small hydrophobic protein, SH, of the paramyxovirus simian virus 5.J Virol. 1985 Sep;55(3):744-51 PMID: 4020965
-
Measles virus: both the haemagglutinin and fusion glycoproteins are required for fusion.J Gen Virol. 1991 Feb;72 ( Pt 2):439-42 PMID: 1993882
-
The haemagglutinin-neuraminidase glycoprotein of the porcine paramyxovirus LPMV: comparison with other paramyxoviruses revealed the closest relationship to simian virus 5 and mumps virus.Arch Virol. 1992;122(3-4):331-40 PMID: 1731697
-
Syncytium formation by recombinant vaccinia viruses carrying bovine parainfluenza 3 virus envelope protein genes.J Virol. 1989 Sep;63(9):3661-8 PMID: 2547990
-
Biological activity of paramyxovirus fusion proteins: factors influencing formation of syncytia.J Virol. 1992 Jul;66(7):4564-9 PMID: 1602561
-
A comprehensive set of sequence analysis programs for the VAX.Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 PMID: 6546423
-
Expression of mumps virus glycoproteins in mammalian cells from cloned cDNAs: both F and HN proteins are required for cell fusion.Virology. 1992 Apr;187(2):801-4 PMID: 1546468
-
Expression at the cell surface of biologically active fusion and hemagglutinin/neuraminidase proteins of the paramyxovirus simian virus 5 from cloned cDNA.Proc Natl Acad Sci U S A. 1985 Nov;82(22):7520-4 PMID: 3865176
-
Complementation between avirulent Newcastle disease virus and a fusion protein gene expressed from a retrovirus vector: requirements for membrane fusion.J Virol. 1991 Feb;65(2):813-22 PMID: 1987376
-
Analysis of respiratory syncytial virus F, G, and SH proteins in cell fusion.Virology. 1994 May 1;200(2):801-5 PMID: 8178462
-
The fusion and hemagglutinin-neuraminidase glycoproteins of human parainfluenza virus 3 are both required for fusion.Virology. 1991 Jul;183(1):437-41 PMID: 1647076
-
Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: roles of conserved residues in cell fusion.J Virol. 1992 Apr;66(4):2443-55 PMID: 1548771
-
Paramyxovirus fusion: a hypothesis for changes.Virology. 1993 Nov;197(1):1-11 PMID: 8212546
-
Sequence of the fusion protein gene of human parainfluenza type 2 virus and its 3' intergenic region: lack of small hydrophobic (SH) gene.Virology. 1990 Sep;178(1):289-92 PMID: 2167555
-
Analysis of the relationship between cleavability of a paramyxovirus fusion protein and length of the connecting peptide.J Virol. 1989 Mar;63(3):1293-301 PMID: 2644448
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
