Structural and functional considerations of the aminoacylation reaction.

Trends in biochemical sciences ·Vol. 22 ·No. 6 ·1997-06-00 ·Pages 211-6

Arnez JG, Moras D

Abstract

Aminoacyl-tRNA synthetases (aaRS) bind their substrates-ATP, amino acids and tRNA- and stabilize putative transition states in the aminoacylation reaction. Here, we discuss the common and distinguishing structural and functional themes of the 20 known aaRS, which can be divided into two main classes (I and II) and into further subgroups on this basis.

MeSH Terms

Adenosine Triphosphate/metabolism Amino Acids/metabolism Amino Acyl-tRNA Synthetases/chemistry,metabolism Anticodon/genetics Binding Sites Hydrogen Bonding Models, Molecular Protein Binding Protein Biosynthesis Protein Conformation Protein Structure, Secondary

Chemicals

Amino Acids Anticodon Adenosine Triphosphate Amino Acyl-tRNA Synthetases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Arnez J G

Laboratoire de Biologie Structurale, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France.

Moras D

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/s0968-0004(97)01052-9

Published

1997-06-00

Pages

211-6

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/s0968-0004(97)01052-9 View journal details

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