Abstract
Although the initial site of poliovirus replication in humans is the intestine, previously isolated transgenic mice which carry the human poliovirus receptor (PVR) gene (TgPVR mice), which develop poliomyelitis after intracerebral inoculation, are not susceptible to infection by the oral route. The low levels of PVR expressed in the TgPVR mouse intestine might explain the absence of poliovirus replication at that site. To ascertain whether PVR is the sole determinant of poliovirus susceptibility of the mouse intestine, we have generated transgenic mice by using the promoter for rat intestine fatty acid binding protein to direct PVR expression in mouse gut. Pvr was detected by immunohistochemistry in the enterocytes and M cells of transgenic mouse (TgFABP-PVR) small intestine. Upon oral inoculation with poliovirus, no increase in virus titer was detected in the feces of TgFABP-PVR mice, and no virus replication was observed in the small intestine, although poliovirus replicated in the brain after intracerebral inoculation. The failure of poliovirus to replicate in the TgFABP-PVR mouse small intestine was not due to lack of virus binding sites, because poliovirus could attach to fragments of small intestine from these mice. These results indicate that the inability of poliovirus to replicate in the mouse alimentary tract is not solely due to the absence of virus receptor, and other factors are involved in determining the ability of poliovirus to replicate in the mouse gut.
MeSH Terms
Animals
Brain/pathology,virology
Disease Susceptibility
Female
Gene Expression
HeLa Cells
Humans
Intestinal Mucosa/cytology,metabolism,virology
Intestine, Small/metabolism,pathology,virology
L Cells
Male
Membrane Proteins
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Transgenic
Poliovirus/physiology
Rats
Receptors, Virus/genetics,metabolism
Virus Replication
Chemicals
Membrane Proteins
Receptors, Virus
poliovirus receptor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zhang S
Department of Microbiology, Columbia University College of Physicians & Surgeons, New York, New York 10032, USA.
Racaniello V R
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