Benzodiazepine receptor: demonstration in the central nervous system.

Science (New York, N.Y.) ·Vol. 198 ·No. 4319 ·1977-11-25 ·Pages 849-51

Möhler H, Okada T

Abstract

Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.

MeSH Terms

Animals Benzodiazepines/metabolism Binding Sites Brain/metabolism,ultrastructure Diazepam/metabolism In Vitro Techniques Molecular Conformation Rats Receptors, Drug/isolation & purification,metabolism Stereoisomerism Structure-Activity Relationship Synaptic Membranes/metabolism Synaptosomes/metabolism Tritium

Chemicals

Receptors, Drug Tritium Benzodiazepines Diazepam

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Möhler H

Okada T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.918669

Published

1977-11-25

Pages

849-51

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.918669 View journal details

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