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题目:: Increased endothelial cell retraction and tumor cell invasion by soluble factors derived from pancreatic cancer cells.
作者:: Nakamori(S),Okamoto(H),Kusama(T),Shinkai(K),Mukai(M),Ohigashi(H),Ishikawa(O),Furukawa(H),Imaoka(S),Akedo(H)
状态:: 发布时间1997-08-07 , 更新时间 2013-11-21
期刊:: Ann Surg Oncol
摘要:: Tumor cells induce endothelial cell retraction before invasion. In pancreatic cancer cells, the factors affecting endothelial cell retraction are not well-understood.,The activities of the endothelial cell retraction in conditioned media (CM) derived from three human pancreatic cancer cell lines, PSN-1, MiaPaca-2, and Capan-1, were measured for the amount of intercellular junctional transport of FITC dextran through an endothelial cell monolayer in a transwell cell culture system.,The CM derived from the three pancreatic cancer cells induced endothelial cell retraction. The endothelial cell retraction activity in the CM from PSN-1 cells was significantly higher than those from MiaPaca-2 and Capan-1 cells. The CM from PSN-1 cells enhanced both the adhesion and the invasion of MiaPaca-2 and Capan-1 cells. The factors with endothelial cell retraction activity in the CM from PSN-1 cells were characterized as heat-stable, trypsin-sensitive glycoproteins ranging from 10,000 to 50,000 in molecular weight, and were found both in heparin-bound and unbound fractions.,PSN-1 cells produced and secreted at least two factors inducing the endothelial cell retraction. The factors could play an important role in the establishment of invasion and metastasis of PSN-1 cells.
语言:: eng
DOI:

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