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PMID: 9169873 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.

Nature ·Vol. 387 ·No. 6632 Suppl ·1997-05-29 ·Pages 93-8

Philippsen P, Kleine K, Pöhlmann R, Düsterhöft A, Hamberg K, Hegemann JH, Obermaier B, Urrestarazu LA, Aert R, Albermann K, Altmann R, André B, Baladron V, Ballesta JP, Bécam AM, Beinhauer J, Boskovic J, Buitrago MJ, Bussereau F, Coster F, Crouzet M, D'Angelo M, Dal Pero F, De Antoni A, Del Rey F, Doignon F, Domdey H, Dubois E, Fiedler T, Fleig U, Floeth M, Fritz C, Gaillardin C, Garcia-Cantalejo JM, Glansdorff NN, Goffeau A, Gueldener U, Herbert C, Heumann K, Heuss-Neitzel D, Hilbert H, Hinni K, Iraqui Houssaini I, Jacquet M, Jimenez A, Jonniaux JL, Karpfinger L, Lanfranchi G, Lepingle A, Levesque H, Lyck R, Maftahi M, Mallet L, Maurer KC, Messenguy F, Mewes HW, Mösti D, Nasr F, Nicaud JM, Niedenthal RK, Pandolfo D, Piérard A, Piravandi E, Planta RJ, Pohl TM, Purnelle B, Rebischung C, Remacha M, Revuelta JL, Rinke M, Saiz JE, Sartorello F, Scherens B, Sen-Gupta M, Soler-Mira A, Urbanus JH, Valle G, Van Dyck L, Verhasselt P, Vierendeels F, Vissers S, Voet M, Volckaert G, Wach A, Wambutt R, Wedler H, Zollner A, Hani J

Abstract

In 1992 we started assembling an ordered library of cosmid clones from chromosome XIV of the yeast Saccharomyces cerevisiae. At that time, only 49 genes were known to be located on this chromosome and we estimated that 80% to 90% of its genes were yet to be discovered. In 1993, a team of 20 European laboratories began the systematic sequence analysis of chromosome XIV. The completed and intensively checked final sequence of 784,328 base pairs was released in April, 1996. Substantial parts had been published before or had previously been made available on request. The sequence contained 419 known or presumptive protein-coding genes, including two pseudogenes and three retrotransposons, 14 tRNA genes, and three small nuclear RNA genes. For 116 (30%) protein-coding sequences, one or more structural homologues were identified elsewhere in the yeast genome. Half of them belong to duplicated groups of 6-14 loosely linked genes, in most cases with conserved gene order and orientation (relaxed interchromosomal synteny). We have considered the possible evolutionary origins of this unexpected feature of yeast genome organization.

MeSH Terms

Base Sequence Chromosomes, Fungal Evolution, Molecular Molecular Sequence Data Multigene Family Open Reading Frames Restriction Mapping Saccharomyces cerevisiae/genetics

Authors & Affiliations

88 authors, click to expand affiliations / ORCID

Philippsen P

Institute for Applied Microbiology, Biozentrum, University of Basel, Switzerland.

Kleine K

Pöhlmann R

Düsterhöft A

Hamberg K

Hegemann J H

Obermaier B

Urrestarazu L A

Aert R

Albermann K

Altmann R

André B

Baladron V

Ballesta J P

Bécam A M

Beinhauer J

Boskovic J

Buitrago M J

Bussereau F

Coster F

Crouzet M

D'Angelo M

Dal Pero F

De Antoni A

Del Rey F

Doignon F

Domdey H

Dubois E

Fiedler T

Fleig U

Floeth M

Fritz C

Gaillardin C

Garcia-Cantalejo J M

Glansdorff N N

Goffeau A

Gueldener U

Herbert C

Heumann K

Heuss-Neitzel D

Hilbert H

Hinni K

Iraqui Houssaini I

Jacquet M

Jimenez A

Jonniaux J L

Karpfinger L

Lanfranchi G

Lepingle A

Levesque H

Lyck R

Maftahi M

Mallet L

Maurer K C

Messenguy F

Mewes H W

Mösti D

Nasr F

Nicaud J M

Niedenthal R K

Pandolfo D

Piérard A

Piravandi E

Planta R J

Pohl T M

Purnelle B

Rebischung C

Remacha M

Revuelta J L

Rinke M

Saiz J E

Sartorello F

Scherens B

Sen-Gupta M

Soler-Mira A

Urbanus J H

Valle G

Van Dyck L

Verhasselt P

Vierendeels F

Vissers S

Voet M

Volckaert G

Wach A

Wambutt R

Wedler H

Zollner A

Hani J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

Published

1997-05-29

Pages

93-8

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

Z71277, Z71278, Z71279, Z71280, Z71281, Z71282, Z71283, Z71284, Z71285, Z71286, Z71287, Z71288, Z71289, Z71290, Z71291, Z71292, Z71293, Z71294, Z71295, Z71296, Z71297, Z71298, Z71299, Z71300, Z71301, Z71302, Z71303, Z71304, Z71305, Z71306

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The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.

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