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PMID: 9159083 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Nuclear export of proteins and RNAs.

Current opinion in cell biology ·Vol. 9 ·No. 3 ·1997-06-00 ·Pages 420-9

Nakielny S, Dreyfuss G

Abstract

Our understanding of protein export from the nucleus to the cytoplasm has been advanced recently by the discovery of active, signal-mediated export pathways. Nuclear export signals have been identified in several proteins, the majority of which are RNA-binding proteins. Nuclear export of RNA molecules is likely to be driven by protein-based nuclear export signals.

MeSH Terms

Amino Acid Sequence Animals Biological Transport Cell Compartmentation Cell Nucleus/metabolism GTP-Binding Proteins/metabolism Humans Molecular Sequence Data Nuclear Envelope/metabolism Nuclear Proteins/metabolism RNA/metabolism RNA Cap-Binding Proteins RNA, Messenger/metabolism RNA, Viral/metabolism RNA-Binding Proteins/metabolism Structure-Activity Relationship ran GTP-Binding Protein

Chemicals

Nuclear Proteins RNA Cap-Binding Proteins RNA, Messenger RNA, Viral RNA-Binding Proteins RNA GTP-Binding Proteins ran GTP-Binding Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Nakielny S

Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6148, USA.

Dreyfuss G

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(97)80016-6

Published

1997-06-00

Pages

420-9

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/s0955-0674(97)80016-6 View journal details

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