Abstract
The presence of the extracellular calcium-sensing receptor on human antral gastrin cells was investigated. Reverse transcription PCR using mRNA isolated from gastrin cell- enriched cell cultures identified a product with a sequence identical to part of the human parathyroid-secreting cell calcium-sensing receptor. Immunocytochemistry with an antibody to the extracellular region of the receptor immunostained all gastrin cells (but not mucin or somatostatin cells), and detected appropriate-sized bands in Western blots of whole cell lysates. Increasing extracellular calcium levels from 0.5 to 9 mM stimulated gastrin release in a concentration-dependent manner, with maximal release obtained at 7.2 mM. A known agonist of the calcium receptor, spermine also stimulated gastrin release. Microfluorimetry of identified gastrin cells demonstrated that increasing extracellular calcium resulted in an initial rapid rise in intracellular calcium followed by a plateau level that returned to basal levels immediately after removal of the elevated calcium. The traces were consistent with activation of a receptor-mediated mechanism rather than a concentration-dependent influx of calcium. In conclusion, these data indicate that G cells express the calcium-sensing receptor, and that activation of the receptor may explain the acid rebound phenomenon associated with calcium-containing antacid preparations.
MeSH Terms
Calcium/metabolism,pharmacology
Calcium-Binding Proteins/analysis,biosynthesis
Cells, Cultured
Gastric Mucosa/cytology,drug effects,physiology
Gastrins/metabolism
Humans
Immunohistochemistry
Kinetics
Polymerase Chain Reaction
Pyloric Antrum
RNA, Messenger/biosynthesis
Spermine/pharmacology
Transcription, Genetic
Chemicals
Calcium-Binding Proteins
Gastrins
RNA, Messenger
Spermine
Calcium
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ray J M
Department of Physiology, University of British Columbia, Vancouver V6T 1Z3, Canada.
Squires P E
Curtis S B
Meloche M R
Buchan A M
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