Home LiteratureArticle Details
PMID: 9145884 Published · ppublish English Comparative Study Journal Article

Multiple antibiotic resistance in Stenotrophomonas maltophilia.

Antimicrobial agents and chemotherapy ·Vol. 41 ·No. 5 ·1997-05-00 ·Pages 1140-2

Alonso A, Martínez JL

Abstract

A cryptic multidrug resistance (MDR) system in Stenotrophomonas maltophilia, the expression of which is selectable by tetracycline, is described. Tetracycline resistance was the consequence of active efflux of the antibiotic, and it was associated with resistance to quinolones and chloramphenicol, but not to aminoglycosides or beta-lactam antibiotics. MDR is linked to the expression of an outer membrane protein (OMP54) both in a model system and in multidrug-resistant clinical isolates.

MeSH Terms
Aminoglycosides Anti-Bacterial Agents/pharmacology Chloramphenicol/pharmacology Drug Resistance, Multiple Lactams Microbial Sensitivity Tests Pseudomonadaceae/drug effects Tetracycline Resistance
Chemicals
Aminoglycosides Anti-Bacterial Agents Lactams Chloramphenicol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Alonso A
Banco de Células, Centro Nacional de Biotecnología (CSIC), Campus UAM, Cantoblanco, Madrid, Spain.
Martínez J L
References (28)
28 references, click to expand
  1. Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction.
    Antimicrob Agents Chemother. 1989 Aug;33(8):1318-25 PMID: 2679373
  2. Proton-dependent multidrug efflux systems.
    Microbiol Rev. 1996 Dec;60(4):575-608 PMID: 8987357
  3. Quinolone antimicrobial agents.
    Annu Rev Med. 1992;43:465-86 PMID: 1580602
  4. Susceptibility of Xanthomonas maltophilia to six quinolones and study of outer membrane proteins in resistant mutants selected in vitro.
    Antimicrob Agents Chemother. 1992 Mar;36(3):669-71 PMID: 1622183
  5. Opportunistic nosocomial multiply resistant bacterial infections--their treatment and prevention.
    J Antimicrob Chemother. 1993 Jul;32 Suppl A:39-47 PMID: 7755661
  6. Prevention of drug access to bacterial targets: permeability barriers and active efflux.
    Science. 1994 Apr 15;264(5157):382-8 PMID: 8153625
  7. Multidrug resistance pumps in bacteria: variations on a theme.
    Trends Biochem Sci. 1994 Mar;19(3):119-23 PMID: 8203018
  8. A changing pattern of susceptibility of Xanthomonas maltophilia to antimicrobial agents: implications for therapy.
    Antimicrob Agents Chemother. 1994 Mar;38(3):624-7 PMID: 8203865
  9. Changing etiology of bacteremia in patients with hematological malignancies in Denmark.
    Scand J Infect Dis. 1994;26(2):157-62 PMID: 8036471
  10. Outer membrane protein profiles of Xanthomonas maltophilia isolates displaying temperature-dependent susceptibility to gentamicin.
    J Antimicrob Chemother. 1994 Mar;33(3):663-6 PMID: 8040133
  11. Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin.
    Antimicrob Agents Chemother. 1994 Aug;38(8):1732-41 PMID: 7986003
  12. The antibiotic susceptibilities of Xanthomonas maltophilia and their relation to clinical management.
    Pathology. 1994 Jul;26(3):321-4 PMID: 7991292
  13. Bacterial colonisation with Xanthomonas maltophilia--a retrospective study in a cystic fibrosis patient population.
    Infection. 1994 Jul-Aug;22(4):258-63 PMID: 8002085
  14. Biochemical properties of inducible beta-lactamases produced from Xanthomonas maltophilia.
    Antimicrob Agents Chemother. 1994 Sep;38(9):2143-9 PMID: 7811033
  15. Efflux pumps and drug resistance in gram-negative bacteria.
    Trends Microbiol. 1994 Dec;2(12):489-93 PMID: 7889326
  16. EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.
    J Bacteriol. 1995 May;177(9):2328-34 PMID: 7730261
  17. Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli.
    J Bacteriol. 1995 Jun;177(12):3414-9 PMID: 7768850
  18. Comparison of E test and agar dilution for antimicrobial susceptibility testing of Stenotrophomonas (Xanthomonas) maltophilia.
    J Clin Microbiol. 1995 May;33(5):1428-30 PMID: 7615774
  19. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.
    Mol Microbiol. 1995 Apr;16(1):45-55 PMID: 7651136
  20. Nosocomial and community-acquired Xanthomonas maltophilia infection in tropical Australia.
    J Hosp Infect. 1995 Aug;30(4):309-13 PMID: 7499812
  21. Xanthomonas maltophilia and Pseudomonas cepacia in lower respiratory tracts of patients in critical care units.
    J Infect. 1995 Sep;31(2):89-92 PMID: 8666858
  22. OprK and OprM define two genetically distinct multidrug efflux systems in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1995 Nov;39(11):2392-6 PMID: 8585714
  23. Stenotrophomonas (Xanthomonas) maltophilia urinary tract infection. A disease that is usually severe and complicated.
    Arch Intern Med. 1996 Feb 26;156(4):433-5 PMID: 8607729
  24. Multidrug resistance in enteric and other gram-negative bacteria.
    FEMS Microbiol Lett. 1996 May 15;139(1):1-10 PMID: 8647368
  25. Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.
    Antimicrob Agents Chemother. 1996 May;40(5):1266-9 PMID: 8723480
  26. Role of anti-pseudomonal antibiotics in the emergence of Stenotrophomonas maltophilia in cystic fibrosis patients.
    Eur J Clin Microbiol Infect Dis. 1996 May;15(5):402-5 PMID: 8793400
  27. Multidrug efflux pumps of gram-negative bacteria.
    J Bacteriol. 1996 Oct;178(20):5853-9 PMID: 8830678
  28. Increase in susceptibility of Pseudomonas aeruginosa to carbapenem antibiotics in low-amino-acid media.
    Antimicrob Agents Chemother. 1991 Mar;35(3):529-32 PMID: 1903911
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.41.5.1140
Published
1997-05-00
Pages
1140-2
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC163865
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.41.5.1140 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2