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题目:: SLAM and its role in T cell activation and Th cell responses.
作者:: Aversa(G),Carballido(J),Punnonen(J),Chang(C C),Hauser(T),Cocks(B G),De Vries(J E)
状态:: 发布时间1997-06-12 , 更新时间 2016-11-24
期刊:: Immunol Cell Biol
摘要:: Following the initial events of T cell activation, triggered by binding of specific peptide-MHC complex to the TCR for antigen and engagement of costimulatory molecules, a number of activation molecules are expressed on the cell surface. Many of these molecules regulate T cell function, T-T cell interactions and the interaction of T cells with other cells. One such molecule is SLAM, a multifunctional 70 kDa glycoprotein member of the Ig superfamily with multiple isoforms. SLAM is rapidly induced on naive T cells and B cells following activation. Engagement of SLAM by a specific antibody (mAb A12) results in IL-2-independent T cell expansion and induction/up-regulation of IFN-gamma by activated T cells, including Th2 cells. SLAM was found to be a high-affinity self-ligand mediating molecular and cellular homophilic interactions. In this review we discuss SLAM as a receptor involved in T cell expansion and in directing immune responses to a Th0-Th1 pathway.
语言:: eng
DOI:: 10.1038/icb.1997.30

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