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PMID: 9105961 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls.

Journal of affective disorders ·Vol. 42 ·No. 2-3 ·1997-02-00 ·Pages 199-207

Lowther S, De Paermentier F, Cheetham SC, Crompton MR, Katona CL, Horton RW

Abstract

5-HT1A receptor binding sites were measured, by saturation binding with [3H]8-OH-DPAT, in frontal and occipital cortex, hippocampus and amygdala obtained at post-mortem examination from suicide victims with a firm retrospective diagnosis of depression, and matched controls. The number of 5-HT1A binding sites did not differ significantly between suicides and controls, either in the total sample or when the suicides were divided on the basis of violence of death or recent antidepressant treatment.

MeSH Terms

Adolescent Adult Aged Amygdala/drug effects,pathology Antidepressive Agents/poisoning,therapeutic use Brain/drug effects,pathology Cause of Death Cerebral Cortex/drug effects,pathology Depressive Disorder/pathology,psychology Drug Overdose/pathology Female Hippocampus/drug effects,pathology Humans Male Middle Aged Postmortem Changes Receptors, Serotonin/analysis,drug effects Receptors, Serotonin, 5-HT1 Suicide/prevention & control,psychology

Chemicals

Antidepressive Agents Receptors, Serotonin Receptors, Serotonin, 5-HT1

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Lowther S

Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.

De Paermentier F

Cheetham S C

Crompton M R

Katona C L

Horton R W

Article Info

Journal

Journal of affective disorders

Abbr.

J Affect Disord

ISSN

0165-0327

DOI

10.1016/s0165-0327(96)01413-9

Published

1997-02-00

Pages

199-207

Language

English

Region

Netherlands

NLM ID

7906073

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1016/s0165-0327(96)01413-9 View journal details

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5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls.

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