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PMID: 9096101 Published · ppublish English Journal Article

The mouse chromosome 7 distal imprinting domain maps to G-bands F4/F5.

Mammalian genome : official journal of the International Mammalian Genome Society ·Vol. 8 ·No. 4 ·1997-04-00 ·Pages 236-40

Beechey CV, Ball ST, Townsend KM, Jones J

Abstract

Mouse Chromosome (Chr) 7 distal to band F3 on the physical map is known to be subject to imprinting, maternal duplication (MatDp) of the region leading to a late embryonic lethality, while paternal duplication (PatDp) causes death in utero before 11.5 dpc. Using a new mouse reciprocal translocation T(7;11)65H to produce MatDp for distal Chr 7, we have mapped the region subject to imprinting more precisely to bands 7F4/F5 on the cytogenetic map. Fluorescence in situ hybridization (FISH) studies on mitotic and meiotic chromosomes of a T65H heterozygote show that the imprinted gene Igf2 is located in the same region. This was confirmed by the finding that embryos with MatDp of bands 7F4/F5 did not express Igf2. We suggest that other members of the imprinted domain containing Igf2, namely Mash2, H19, Ins2, and p57(K1P2), are also located in 7F4/F5 and that some or all of these genes may be responsible for the two imprinting lethalities seen with MatDp and PatDp for this region.

MeSH Terms
Animals Chromosome Banding Chromosome Mapping Embryo, Mammalian Female Genomic Imprinting In Situ Hybridization, Fluorescence Insulin-Like Growth Factor II/genetics Male Meiosis Mice Mitosis Phenotype Translocation, Genetic
Chemicals
Insulin-Like Growth Factor II
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Beechey C V
Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxfordshire OX11 0RD, UK.
Ball S T
Townsend K M
Jones J
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Article Info
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Abbr.
Mamm Genome
ISSN
0938-8990
DOI
10.1007/s003359900400
Published
1997-04-00
Pages
236-40
Language
English
Region
United States
NLM ID
9100916
Subset
IM
External Links
PubMed source DOI: 10.1007/s003359900400 View journal details
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