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PMID: 9095001 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Genetic changes in intraductal breast cancer detected by comparative genomic hybridization.

The American journal of pathology ·Vol. 150 ·No. 4 ·1997-04-00 ·Pages 1465-71

Kuukasjärvi T, Tanner M, Pennanen S, Karhu R, Kallioniemi OP, Isola J

Abstract

Ductal carcinoma in situ (DCIS) is considered a direct precursor of invasive ductal breast cancer (IDC). We combined tissue microdissection and comparative genomic hybridization to identify genetic changes in five DCIS lesions with no invasion and in two that were adjacent to IDC. Extensive genetic changes characterized pure DCIS cases with gains of 1q, 6q, 8q, and Xq as well as losses of 17p and chromosome 22 being most often involved. Except for the Xq gain, these changes are also common to IDC. Separate analysis of DCIS and IDC components in the same tumor revealed an almost identical pattern of genetic changes in one case, whereas substantial differences were found in another. We conclude that many of the common genetic changes in IDC may take place before development of invasive growth. However, a simple linear progression model may not always account for the DCIS-IDC transition.

MeSH Terms
Breast Neoplasms/genetics,pathology Carcinoma in Situ/genetics,pathology Carcinoma, Ductal, Breast/genetics,pathology Carcinoma, Intraductal, Noninfiltrating/genetics,pathology Chromosome Mapping Female Humans In Situ Hybridization, Fluorescence Nucleic Acid Hybridization Polymerase Chain Reaction
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kuukasjärvi T
Department of Pathology, Tampere University Hospital, University of Tampere, Finland.
Tanner M
Pennanen S
Karhu R
Kallioniemi O P
Isola J
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1997-04-00
Pages
1465-71
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1858157
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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