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PMID: 9094701 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice.

Journal of virology ·Vol. 71 ·No. 5 ·1997-05-00 ·Pages 4161-4

Gulizia RJ, Collman RG, Levy JA, Trono D, Mosier DE

Abstract

The pathogenicity of four human immunodeficiency virus type 1 (HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of plasma viremia in infected hu-PBL-SCID mice. Deletion of the nef gene impacts both the efficiency of primary infection and the cytopathicity of virus for infected CD4-positive T cells in this animal model of HIV-1 infection.

MeSH Terms
Acquired Immunodeficiency Syndrome/immunology Animals CD4-Positive T-Lymphocytes/physiology Gene Deletion Genes, nef/physiology HIV-1 Humans Leukocytes/virology Mice Mice, SCID RNA, Viral/analysis
Chemicals
RNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Gulizia R J
Department of Immunology-IMM7, The Scripps Research Institute, La Jolla, California 92037, USA.
Collman R G
Levy J A
Trono D
Mosier D E
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.71.5.4161-4164.1997
Published
1997-05-00
Pages
4161-4
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC191576
Subset
IM
Grants
NIAID NIH HHS · AI-29182 · United States
External Links
PubMed source DOI: 10.1128/JVI.71.5.4161-4164.1997 PMC Full Text View journal details
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