Role of sialic acid in saliva-induced aggregation of Streptococcus sanguis.

Infection and immunity ·Vol. 18 ·No. 1 ·1977-10-00 ·Pages 35-40

McBride BC, Gisslow MT

Abstract

The ability of saliva to induce aggregation of Streptococcus sanguis was destroyed by treating the saliva with protease or neuraminidase. Loss of aggregating activity could be correlated with the appearance of free sialic acid. Clarified saliva contains an endogenous neuraminidase that modifies aggregating activity. Aggregation was inhibited by mixed ganglioside preparations but less effectively by acid-hydrolyzed gangliosides. The aggregating activity of S. sanguis was not related to the rhamnose or phosphorous content of the cell wall or to antigen a, b, c, d, or e.

MeSH Terms

Binding Sites Binding, Competitive Cell Wall/metabolism Gangliosides/pharmacology Glycoproteins/metabolism Humans Neuraminidase/metabolism Saliva/enzymology,metabolism Sialic Acids/metabolism Streptococcus sanguis/metabolism,ultrastructure

Chemicals

Gangliosides Glycoproteins Sialic Acids Neuraminidase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

McBride B C

Gisslow M T

References (13)

13 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.18.1.35-40.1977

Published

1977-10-00

Pages

35-40

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC421189

Subset

External Links

PubMed source DOI: 10.1128/iai.18.1.35-40.1977 PMC Full Text View journal details

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Role of sialic acid in saliva-induced aggregation of Streptococcus sanguis.

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