Cell cycle: will the real Cdk-activating kinase please stand up.

Current biology : CB ·Vol. 7 ·No. 1 ·1997-01-01 ·Pages R50-2

Draetta GF

Abstract

Activation of a cyclin-dependent kinase (Cdk) requires its association with a cyclin subunit and phosphorylation on a conserved residue by the Cdk-activating kinase (CAK). The discovery in budding yeast of a novel CAK that is structurally distinct from the CAKs of other eukaryotes raises questions about the 'true' CAK.

MeSH Terms

Cell Cycle/physiology Cyclin-Dependent Kinases/physiology Protein Serine-Threonine Kinases/physiology Saccharomyces cerevisiae/physiology

Chemicals

Protein Serine-Threonine Kinases Cyclin-Dependent Kinases cyclin-dependent kinase-activating kinase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Draetta G F

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. gdraetta@ieo.cilea.it

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(06)00020-0

gdraetta@ieo.cilea.it

Published

1997-01-01

Pages

R50-2

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(06)00020-0 View journal details

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Cell cycle: will the real Cdk-activating kinase please stand up.

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