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PMID: 9066257 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The evolution of ribonucleotide reduction.

Trends in biochemical sciences ·Vol. 22 ·No. 3 ·1997-03-00 ·Pages 81-5

Reichard P

Abstract

Ribonucleotide reduction was essential for the transition from RNA to DNA by supplying deoxyribonucleotide precursors. The reaction requires free radical chemistry. Three quite different classes of ribonucleotide reductases are known today. All three are proteins containing a stable free radical amino acid, but each uses a different mechanism for its generation. Did they evolve from a common ancestor, with the arrival of atmospheric oxygen providing the driving force for their divergence, or was each a separate evolutionary invention?

MeSH Terms
Escherichia coli/enzymology Evolution, Molecular Lactobacillus/enzymology Oxidation-Reduction Ribonucleotide Reductases/chemistry,classification,metabolism Ribonucleotides/chemistry,metabolism Substrate Specificity
Chemicals
Ribonucleotides Ribonucleotide Reductases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Reichard P
Medical Nobel Institute for Biochemistry, Karolinska Institutet, Stockholm, Sweden. peter.reichard@mbb.ki.se
Article Info
Journal
Trends in biochemical sciences
Abbr.
Trends Biochem Sci
ISSN
0968-0004
Published
1997-03-00
Pages
81-5
Language
English
Region
England
NLM ID
7610674
Subset
IM
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