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PMID: 9052839 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).

Immunity ·Vol. 6 ·No. 1 ·1997-01-00 ·Pages 79-88

Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J

Abstract

A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to signal apoptosis. Overexpression of TRAMP leads to two major responses, NF-kappaB activation and apoptosis. TRAMP-induced cell death is inhibited by an inhibitor of ICE-like proteases, but not by Bcl-2. In addition, TRAMP does not appear to interact with any of the known apoptosis-inducing ligands of the TNF family.

MeSH Terms
Adaptor Proteins, Signal Transducing Amino Acid Sequence Apoptosis Apoptosis Regulatory Proteins Carrier Proteins/metabolism Chromosomes, Human, Pair 1 Cytoplasm/chemistry Fas Ligand Protein Fas-Associated Death Domain Protein Gene Expression Humans Ligands Lymphocytes/physiology Membrane Glycoproteins/metabolism Molecular Sequence Data Multigene Family NF-kappa B/physiology RNA, Messenger/genetics Receptors, Cell Surface/physiology Receptors, Tumor Necrosis Factor/genetics,physiology Receptors, Tumor Necrosis Factor, Member 25 Sequence Alignment Sequence Homology, Amino Acid Signal Transduction TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha/metabolism
Chemicals
Adaptor Proteins, Signal Transducing Apoptosis Regulatory Proteins Carrier Proteins FADD protein, human FASLG protein, human Fas Ligand Protein Fas-Associated Death Domain Protein Ligands Membrane Glycoproteins NF-kappa B RNA, Messenger Receptors, Cell Surface Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor, Member 25 TNF-Related Apoptosis-Inducing Ligand TNFRSF25 protein, human TNFSF10 protein, human Tumor Necrosis Factor-alpha
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Bodmer J L
Institute of Biochemistry, University of Lausanne, Switzerland.
Burns K
Schneider P
Hofmann K
Steiner V
Thome M
Bornand T
Hahne M
Schröter M
Becker K
Wilson A
French L E
Browning J L
MacDonald H R
Tschopp J
Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1074-7613
Published
1997-01-00
Pages
79-88
Language
English
Region
United States
NLM ID
9432918
Subset
IM
Databases
GENBANK
U75380, U75381
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