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PMID: 9045744 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Group I metabotropic glutamate receptors mGluR1alpha and mGluR5a: localization in both synaptic layers of the rat retina.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 17 ·No. 6 ·1997-03-15 ·Pages 2200-11

Koulen P, Kuhn R, Wässle H, Brandstätter JH

Abstract

We examined the distribution of the group I metabotropic glutamate receptors, mGluR1alpha and mGluR5a, in the adult rat retina and during postnatal development using receptor-specific antisera. In contrast to the restricted localization of group II and group III mGluRs to either the outer plexiform layer (OPL) or the inner plexiform layer (IPL), group I mGluRs are present in both synaptic layers in the rat retina. Double-labeling experiments and electron microscopy showed that in the OPL the two receptors are localized on the dendritic tips of bipolar cells postsynaptic to photoreceptor terminals. In the IPL the two mGluRs are localized on amacrine cell processes postsynaptic to bipolar cell terminals. These results suggest that group I mGluRs are involved in synaptic processing in both plexiform layers and in both the scotopic and photopic pathways in the rat retina. We propose that mGluR1alpha and mGluR5a play an important modulatory role in the responses of retinal neurons to inhibitory and excitatory neurotransmitters.

MeSH Terms
Animals Immunohistochemistry Microscopy, Electron Presynaptic Terminals/metabolism,ultrastructure Rats Receptors, Metabotropic Glutamate/metabolism Retina/metabolism
Chemicals
Receptors, Metabotropic Glutamate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Koulen P
Max-Planck-Institut für Hirnforschung, Abteilung für Neuroanatomie, D-60528 Frankfurt am Main, Germany.
Kuhn R
Wässle H
Brandstätter J H
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1997-03-15
Pages
2200-11
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6793758
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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