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PMID: 9042906 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Congenital anomalies and childhood cancer in Great Britain.

American journal of human genetics ·Vol. 60 ·No. 3 ·1997-03-00 ·Pages 474-85

Narod SA, Hawkins MM, Robertson CM, Stiller CA

Abstract

The presence of cancer and a congenital anomaly in the same child may be explained in certain cases by an underlying genetic abnormality. The study of these associations may lead to the identification of genes that are important in both processes. We have examined the records of 20,304 children with cancer in Britain, who were entered into the National Registry of Childhood Tumors (NRCT) during 1971-86, for the presence of congenital anomalies. The frequency of anomalies was much higher among children with solid tumors (4.4%) than among those with leukemia or lymphoma (2.6%; P < .0001). The types of cancer with the highest rates of anomalies were Wilms tumor (8.1%), Ewing sarcoma (5.8%), hepatoblastoma (6.4%), and gonadal and germ-cell tumors (6.4%). Cases of spina bifida and abnormalities of the eye, ribs, and spine were more common in children with cancer than among population-based controls. Future studies may be directed toward identifying the developmental pathways and the relevant genes that are involved in the overlap between pediatric cancer and malformation.

MeSH Terms
Adolescent Child Child, Preschool Congenital Abnormalities/epidemiology,genetics Humans Infant Neoplasms/complications,epidemiology,genetics Registries United Kingdom
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Narod S A
Department of Preventive Medicine and Biostatistics, University of Toronto. narod@ftn.net
Hawkins M M
Robertson C M
Stiller C A
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Email
narod@ftn.net
Published
1997-03-00
Pages
474-85
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1712528
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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