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PMID: 9032402 Published · ppublish English Journal Article

Suppression of apoptotic DNA fragmentation in herpes simplex virus type 1-infected cells.

Journal of virology ·Vol. 71 ·No. 3 ·1997-03-00 ·Pages 2567-71

Koyama AH, Miwa Y

Abstract

HEp-2 cells underwent apoptosis when the cells were incubated in medium containing sorbitol. Infection with herpes simplex virus type 1 (HSV-1) prior to the sorbitol treatment suppressed this apoptosis completely, indicating that HSV-1 carries an antiapoptosis gene. In addition, HSV-1 multiplication was restricted in these apoptotic HEp-2 cells.

MeSH Terms
Apoptosis/physiology DNA Fragmentation Herpesvirus 1, Human/genetics,growth & development,physiology Humans Mutagenesis Sorbitol/pharmacology Tumor Cells, Cultured Viral Proteins/genetics,metabolism
Chemicals
Viral Proteins gamma 34.5 protein, Human herpesvirus 1 Sorbitol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Koyama A H
Department of Virology, School of Medicine, The University of Tokushima, Japan. koyama@basic.med.tokushima-u.ac.jp
Miwa Y
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.71.3.2567-2571.1997
Email
koyama@basic.med.tokushima-u.ac.jp
Published
1997-03-00
Pages
2567-71
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC191375
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.71.3.2567-2571.1997 PMC Full Text View journal details
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