Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene.

Binding Sites Cell Hypoxia/genetics Cell Line DNA-Binding Proteins/metabolism Endothelial Growth Factors/genetics Gene Expression Regulation/drug effects Genes, Tumor Suppressor Humans Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Ligases Lymphokines/genetics Metals/pharmacology Molecular Sequence Data Nuclear Proteins/metabolism Promoter Regions, Genetic Proteins/genetics,metabolism RNA, Messenger/genetics,metabolism Second Messenger Systems Transcription Factors Tumor Suppressor Proteins Ubiquitin-Protein Ligases Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Von Hippel-Lindau Tumor Suppressor Protein von Hippel-Lindau Disease/genetics

DNA-Binding Proteins Endothelial Growth Factors HIF1A protein, human Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Lymphokines Metals Nuclear Proteins Proteins RNA, Messenger Transcription Factors Tumor Suppressor Proteins Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Ubiquitin-Protein Ligases Von Hippel-Lindau Tumor Suppressor Protein Ligases VHL protein, human