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PMID: 9016875 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Negative selection in the thymus includes semimature T cells.

The Journal of experimental medicine ·Vol. 185 ·No. 2 ·1997-01-20 ·Pages 263-71

Kishimoto H, Sprent J

Abstract

The thymic medulla plays a key role in negative selection (self-tolerance induction) and contains differentiated T cells en route to the extrathymic environment. However, being relatively mature, medullary T cells are thought to be beyond the stage of tolerance induction. This paradox is resolved by the finding that medullary T cells (CD4+8- thymocytes) comprise two distinct subsets. Medullary thymocytes expressing a fully mature (HSAlo) phenotype are strongly resistant to tolerance induction, whereas cells with a semimature (HSAhi) phenotype are tolerance susceptible. These findings suggest that the differentiated T cells reaching the medulla from the cortex remain sensitive to tolerance induction for a brief period before acquiring a fully mature tolerance-resistant phenotype. The semimature subset of medullarsy T cells displays unique requirements for tolerance induction; depending upon the conditions used, tolerizing these cells can involve either a Fas (CD95)-dependent or a Fas-independent pathway.

MeSH Terms
Animals CD4-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Mice Mice, Inbred Strains Receptors, Antigen, T-Cell/immunology T-Lymphocyte Subsets Thymus Gland/immunology
Chemicals
Receptors, Antigen, T-Cell
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kishimoto H
Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037, USA.
Sprent J
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48 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.185.2.263
Published
1997-01-20
Pages
263-71
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2196120
Subset
IM
Grants
NIAID NIH HHS · AI21487 · United States
NCI NIH HHS · CA25803 · United States
NCI NIH HHS · CA38355 · United States
External Links
PubMed source DOI: 10.1084/jem.185.2.263 PMC Full Text View journal details
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