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PMID: 9007972 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Friends and relations of the cystatin superfamily--new members and their evolution.

Protein science : a publication of the Protein Society ·Vol. 6 ·No. 1 ·1997-01-00 ·Pages 5-12

Brown WM, Dziegielewska KM

Abstract

The cystatin "superfamily" encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. In recent years, several new members of the superfamily have characterized, including proteins from insects and plants. Based on partial amino acid homology, new members, such as the invariant chain (Ii), and the transforming growth factor-beta receptor type II (TGF-beta receptor II) may, in fact, represent members of an emerging family within the superfamily that may have used some common building blocks to form functionally diverse proteins. Cystatin super-family members have been found throughout evolution and members of each family of the superfamily are present in mammals today. In this review, the new and older, established members of the family are arranged into a possible evolutionary order, based on sequence homology and functional similarities.

MeSH Terms
Amino Acid Sequence Animals Conserved Sequence Cystatins/chemistry,genetics Evolution, Molecular Humans Plants/chemistry alpha-Fetoproteins/chemistry
Chemicals
Cystatins alpha-Fetoproteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Brown W M
Department of Anatomy and Physiology, University of Tasmania, Hobart, Australia.
Dziegielewska K M
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Article Info
Journal
Protein science : a publication of the Protein Society
Abbr.
Protein Sci
ISSN
0961-8368
DOI
10.1002/pro.5560060102
Published
1997-01-00
Pages
5-12
Language
English
Region
United States
NLM ID
9211750
PMCID
PMC2143511
Subset
IM
External Links
PubMed source DOI: 10.1002/pro.5560060102 PMC Full Text View journal details
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