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PMID: 9003396 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.

The Biochemical journal ·Vol. 321 ( Pt 1) ·1997-01-01 ·Pages 17-20

Kietzmann T, Roth U, Freimann S, Jungermann K

Abstract

Liver glucokinase (GK) is localized predominantly in the perivenous zone. GK mRNA was induced by insulin maximally under venous O2 partial pressure (pO2) and only half-maximally under arterial pO2. CoCl2 and desferrioxamine mimicked venous pO2 and enhanced the insulin-dependent induction of GK mRNA under arterial pO2. H2O2 mimicked arterial pO2 and reduced insulin-induced GK mRNA under venous pO2 to the lower arterial levels. Thus the zonal O2 gradient in liver seems to have a key role in the heterogenous expression of the GK gene.

MeSH Terms

Animals Antimutagenic Agents/pharmacology Blood Gas Monitoring, Transcutaneous Cobalt Deferoxamine/pharmacology Enzyme Induction Gene Expression Regulation, Enzymologic/drug effects Glucokinase/metabolism Hydrogen Peroxide/pharmacology Insulin/pharmacology Liver/enzymology Male RNA, Messenger/metabolism Rats Rats, Wistar

Chemicals

Antimutagenic Agents Insulin RNA, Messenger Cobalt Hydrogen Peroxide Glucokinase cobaltous chloride Deferoxamine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kietzmann T

Institut für Biochemie und Molekulare Zellbiologie, Göttingen, Federal Republic of Germany.

Roth U

Freimann S

Jungermann K

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj3210017

Published

1997-01-01

Pages

17-20

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1218031

Subset

External Links

PubMed source DOI: 10.1042/bj3210017 PMC Full Text View journal details

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Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.

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