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PMID: 8987782 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Pathway-specific synaptic plasticity: activity-dependent enhancement and suppression of long-term heterosynaptic facilitation at converging inputs on a single target.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 17 ·No. 2 ·1997-01-15 ·Pages 597-606

Schacher S, Wu F, Sun ZY

Abstract

To explore mechanisms of long-term, pathway-specific synaptic plasticity, we examined consequences of differential stimulation of Aplysia sensorimotor connections in culture where two sensory neuron (SN) inputs converge on a single target motor cell L7. A single pairing of tetanus in one SN with bath application of 5-HT evoked long-term (24 hr) increase in efficacy of the SN connection given paired stimulation that was comparable in magnitude to the increase in synaptic efficacy evoked with repeated applications of 5-HT. Repeated pairing of tetanus in one SN with applications of 5-HT evoked a significant increase in efficacy of the SN connection given paired stimuli, and significant reduction in facilitation that is normally evoked by repeated applications of 5-HT in the unpaired SN connection. Hyperpolarization of L7 or incubation with APV interfered with both enhancement of facilitation with paired stimulation and suppression of facilitation with unpaired stimulation, but without interfering with long-term facilitation evoked either by repeated applications of 5-HT or by a single pairing. The results suggest that a single connection can undergo at least two forms of activity-dependent, pathway-specific facilitation lasting more than 24 hr. One form, evoked with a single pairing, is initiated and maintained primarily by activity in the presynaptic neuron. The other form, evoked with repeated paired stimuli, requires target-dependent activity that differentially modulates long-term heterosynaptic facilitation at the converging inputs.

MeSH Terms
2-Amino-5-phosphonovalerate/pharmacology Action Potentials/drug effects Animals Aplysia/drug effects,physiology Electric Stimulation Ganglia, Invertebrate/cytology,physiology Long-Term Potentiation/drug effects,physiology Mechanoreceptors/drug effects,physiology Models, Neurological Muscle Contraction/drug effects Neuromuscular Junction/physiology Neurons, Afferent/drug effects,physiology Serotonin/pharmacology
Chemicals
Serotonin 2-Amino-5-phosphonovalerate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schacher S
Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Wu F
Sun Z Y
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1997-01-15
Pages
597-606
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6573247
Subset
IM
Grants
NIGMS NIH HHS · GM 32099 · United States
External Links
PubMed source PMC Full Text View journal details
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