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PMID: 8985012 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development.

Science (New York, N.Y.) ·Vol. 275 ·No. 5297 ·1997-01-10 ·Pages 203-6

Penton A, Selleck SB, Hoffmann FM

Abstract

In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-beta-related gene decapentaplegic (dpp) was required for the synchronization of the cell cycle but not for cell fate specification. DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye.

MeSH Terms
Animals Body Patterning Cell Cycle Cell Differentiation Cell Nucleus/ultrastructure Cyclins/metabolism Drosophila/genetics,physiology Drosophila Proteins Eye/cytology Female G1 Phase G2 Phase Genes, Insect Insect Proteins/genetics,physiology Male Membrane Glycoproteins/genetics,physiology Mitosis Mutation Photoreceptor Cells, Invertebrate/cytology Proteoglycans/genetics,physiology Signal Transduction
Chemicals
Cyclins Drosophila Proteins Insect Proteins Membrane Glycoproteins Proteoglycans dally protein, Drosophila dpp protein, Drosophila
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Penton A
McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA.
Selleck S B
Hoffmann F M
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.275.5297.203
Published
1997-01-10
Pages
203-6
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.275.5297.203 View journal details
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