Abstract
1. Whole-cell clamp experiments on Purkinje neurons in rat cerebellar slices were used to test whether glutamate transporters, detected immunocytochemically in the somata and dendrites of the cells, are functional in the cell surface membrane, and to investigate their role in terminating synaptic transmission. 2. A membrane current was detected with the pharmacology, voltage and ion dependence of a glutamate uptake current. Part of the current was generated by an anion conductance activated when uptake occurs. 3. With sodium and glutamate inside the cell, raising the external potassium concentration generated an outward current attributable to reversed operation of glutamate transporters. 4. The magnitude of the uptake current suggested that Purkinje cell transporters could help to terminate transmission at the climbing and parallel fibre to Purkinje cell synapses. Reducing postsynaptic glutamate uptake with intracellular D-aspartate prolonged the climbing fibre EPSC. 5. These data establish the existence of functional postsynaptic glutamate transporters, show that they contribute to terminating synaptic transmission, and suggest that they may play a role in the preferential death of Purkinje cells in ischaemia.
MeSH Terms
2-Amino-5-phosphonovalerate/pharmacology
6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
Animals
Aspartic Acid/pharmacology
Benzoates/pharmacology
Cycloleucine/analogs & derivatives,pharmacology
Electrophysiology
Excitatory Amino Acid Antagonists/pharmacology
Glutamic Acid/pharmacokinetics
Glycine/analogs & derivatives,pharmacology
Ion Channel Gating/physiology
Kynurenic Acid/pharmacology
Membrane Potentials/drug effects,physiology
Monosaccharide Transport Proteins/metabolism
Neuroprotective Agents/pharmacology
Purkinje Cells/metabolism,physiology,ultrastructure
Rats
Receptors, Metabotropic Glutamate/antagonists & inhibitors
Synaptic Transmission/drug effects,physiology
Tetrodotoxin/pharmacology
Chemicals
Benzoates
Excitatory Amino Acid Antagonists
Monosaccharide Transport Proteins
Neuroprotective Agents
Receptors, Metabotropic Glutamate
Cycloleucine
1-amino-1,3-dicarboxycyclopentane
alpha-methyl-4-carboxyphenylglycine
Aspartic Acid
Glutamic Acid
Tetrodotoxin
6-Cyano-7-nitroquinoxaline-2,3-dione
2-Amino-5-phosphonovalerate
Kynurenic Acid
Glycine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Takahashi M
Department of Physiology, University College London, UK.
Sarantis M
Attwell D
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