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PMID: 8953257 Published · ppublish English Journal Article

Parallel computation enables precise description of Ca2+ distribution in nerve terminals.

Bulletin of mathematical biology ·Vol. 58 ·No. 6 ·1996-11-00 ·Pages 1075-97

Aharon S, Bercovier M, Parnas H

Abstract

Parallel computation employing a domain decomposition method was used to calculate precisely without approximations the spatio-temporal distribution of Ca2+ in nerve terminals. The results showed, contrary to expectations, that for equal admitted Ca2+ currents at low (one channel open) and high (four channels open) depolarization, the average Ca2+ concentration at the release area is higher at the low depolarization. These calculations provide additional support for the Ca(2+)-voltage hypothesis for neurotransmitter release.

MeSH Terms
Animals Calcium/metabolism Mathematics Membrane Potentials Models, Neurological Nerve Endings/physiology Neurotransmitter Agents/metabolism
Chemicals
Neurotransmitter Agents Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Aharon S
Department of Neurobiology, Hebrew University, Givat Ram, Jerusalem, Israel.
Bercovier M
Parnas H
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Article Info
Journal
Bulletin of mathematical biology
Abbr.
Bull Math Biol
ISSN
0092-8240
DOI
10.1007/BF02458384
Published
1996-11-00
Pages
1075-97
Language
English
Region
United States
NLM ID
0401404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02458384 View journal details
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