Home LiteratureArticle Details
PMID: 8940263 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Individual variation in recombination among human males.

American journal of human genetics ·Vol. 59 ·No. 6 ·1996-12-00 ·Pages 1186-92

Yu J, Lazzeroni L, Qin J, Huang MM, Navidi W, Erlich H, Arnheim N

Abstract

Studies of recombination between the markers D6S291 and D6S109 in individuals by sperm typing provide direct evidence for significant variation in recombination among humans. A statistically significant difference in the recombination fraction (range 5.1%-11.2%) was detected among five donors. This variation could reflect polymorphisms in genes affecting recombination or in chromosome structure. Ignoring this variability in studies designed to examine the relationship between physical and genetic distances could lead to incorrect inferences. Individual variation in recombination makes it difficult to predict the recombination fraction for an interval in any particular individual. This could be important in certain genetic counseling situations.

MeSH Terms
Adult Genetic Markers Genetic Variation/genetics Humans Likelihood Functions Male Middle Aged Recombination, Genetic/genetics Spermatozoa
Chemicals
Genetic Markers
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Yu J
Molecular Biology Program, University of Southern California, Los Angeles 90089-1340, USA.
Lazzeroni L
Qin J
Huang M M
Navidi W
Erlich H
Arnheim N
References (20)
20 references, click to expand
  1. Allelic specific heterogeneity in the Pi:Gm linkage group.
    Cytogenet Cell Genet. 1978;22(1-6):647-50 PMID: 313312
  2. Further studies on bivalent chiasma frequency in human males with normal karyotypes.
    Ann Hum Genet. 1985 Jul;49(Pt 3):189-201 PMID: 4073833
  3. A genetic linkage map of the human genome.
    Cell. 1987 Oct 23;51(2):319-37 PMID: 3664638
  4. Amplification and analysis of DNA sequences in single human sperm and diploid cells.
    Nature. 1988 Sep 29;335(6189):414-7 PMID: 3419517
  5. Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers.
    Proc Natl Acad Sci U S A. 1989 Dec;86(23):9389-93 PMID: 2574460
  6. Recombination events suggest potential sites for the Huntington's disease gene.
    Neuron. 1989 Aug;3(2):183-90 PMID: 2576211
  7. The Gm-Pi linkage in 843 French families: effect of the alleles Pi Z and Pi S.
    Ann Hum Genet. 1990 May;54(Pt 2):107-13 PMID: 2382967
  8. Sex, strain, and species differences affect recombination across an evolutionarily conserved segment of mouse chromosome 16.
    Genomics. 1990 Sep;8(1):141-8 PMID: 1981993
  9. A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates.
    Am J Hum Genet. 1991 May;48(5):911-25 PMID: 1673289
  10. XY chromosome nondisjunction in man is associated with diminished recombination in the pseudoautosomal region.
    Am J Hum Genet. 1991 Aug;49(2):253-60 PMID: 1867189
  11. Ordering three DNA polymorphisms on human chromosome 3 by sperm typing.
    Genomics. 1991 Jul;10(3):748-55 PMID: 1679751
  12. Whole genome amplification from a single cell: implications for genetic analysis.
    Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5847-51 PMID: 1631067
  13. A new source of polymorphic DNA markers for sperm typing: analysis of microsatellite repeats in single cells.
    Am J Hum Genet. 1992 Nov;51(5):985-91 PMID: 1415267
  14. Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: do double crossovers occur during male meiosis?
    Am J Hum Genet. 1994 Sep;55(3):423-30 PMID: 8079986
  15. Multipoint mapping calculations for sperm-typing data.
    Am J Hum Genet. 1994 Sep;55(3):431-6 PMID: 8079987
  16. Genetic mapping of F13A to BTA23 by sperm typing: difference in recombination rate between bulls in the DYA-PRL interval.
    Genomics. 1995 May 1;27(1):113-8 PMID: 7665157
  17. Allele-dependent recombination frequency: homology requirement in meiotic recombination at the hot spot in the mouse major histocompatibility complex.
    Genomics. 1995 May 20;27(2):298-305 PMID: 7557996
  18. How is the Human Genome Project doing, and what have we learned so far?
    Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10841-8 PMID: 7479895
  19. Recombination fractions in the HLA system based on the data set 'provinces Françaises': indications of haplotype-specific recombination rates.
    Eur J Immunogenet. 1994 Feb;21(1):33-43 PMID: 9098418
  20. Autosomal linkage between the Gm and Pi loci in man.
    Ann Hum Genet. 1972 Apr;35(4):393-9 PMID: 5073686
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1996-12-00
Pages
1186-92
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1914855
Subset
IM
Grants
NIGMS NIH HHS · R01-GM-53275 · United States
NIGMS NIH HHS · R37-GM-36745 · United States
Corrections
CommentIn
PMID: 8940261
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2