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PMID: 8939717 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Development of the hematopoietic system.

Current opinion in genetics & development ·Vol. 6 ·No. 5 ·1996-10-00 ·Pages 597-602

Orkin SH

Abstract

Significant advances have been made in the past year in understanding hematopoietic development. Recent studies have clarified the origin and migration of stem cells in early embryos, established potential roles for homeodomain proteins in controlling the proliferation of progenitor cells and in patterning ventral mesoderm, and demonstrated the effects of nuclear proteins on lineage programming and apoptosis.

MeSH Terms

Animals Apoptosis Cell Differentiation Cell Division Cell Survival Embryonic and Fetal Development Genes, Homeobox Hematopoiesis Hematopoietic Stem Cells/cytology,physiology Homeodomain Proteins/physiology Humans Mesoderm/physiology Models, Biological Stem Cells/cytology,physiology

Chemicals

Homeodomain Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Orkin S H

Howard Hughes Medical Institute, Division of Hematology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. Orkin@rascal.med.harvard.edu

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(96)80089-x

orkin@rascal.med.harvard.edu

Published

1996-10-00

Pages

597-602

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/s0959-437x(96)80089-x View journal details

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Development of the hematopoietic system.

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