Home LiteratureArticle Details

PMID: 8938713 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Eight potassium channel families revealed by the C. elegans genome project.

Neuropharmacology ·Vol. 35 ·No. 7 ·1996-00-00 ·Pages 805-29

Wei A, Jegla T, Salkoff L

Abstract

The wealth of accumulating data from the Caenorhabditis elegans genome sequencing project has rapidly accelerated the discovery of novel potassium channel genes and now places within reach the possibility of describing the total complement of potassium channels used by an individual species. Using annotated GenBank sequences, BLAST searches of unfinished sequences and degenerate oligonucleotide polymerase chain reaction (PCR) screens, we have identified and compiled genes for 38 C. elegans potassium channel and two cyclic nucleotide-gated cation channel subunits, representing eight conserved multigene families. Novel families of potassium channel genes were revealed, as well as conserved homologues of all known vertebrate families. Two separate families represent C. elegans homologues for human potassium channels recently implicated in hereditary long QT arrhythmias. Of particular note is an exceptionally large class of at least 23 genes with a novel subunit structure having two tandem 'P' domains; these channels may form as dimers in contrast to all other potassium channel types which form as tetramers. The 40 potassium channel genes are evenly distributed on all six C. elegans chromosomes, with the exception of the instances of gene clustering on the fifth and X chromosomes.

MeSH Terms

Amino Acid Sequence Animals Caenorhabditis elegans/genetics Conserved Sequence Genes, Helminth Humans Ion Channel Gating Molecular Sequence Data Potassium Channels/genetics

Chemicals

Potassium Channels

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wei A

Department of Anatomy and Neurobiology, Washington University, School of Medicine, Saint Louis, MO 63110, USA.

Jegla T

Salkoff L

Article Info

Journal

Neuropharmacology

Abbr.

Neuropharmacology

ISSN

0028-3908

DOI

10.1016/0028-3908(96)00126-8

Published

1996-00-00

Pages

805-29

Language

English

Region

England

NLM ID

0236217

Subset

Databases

GENBANK

A48206, D50581, H23701, L25264, M17211, M32659, M32660, M32661, M69053, M86990, P35560, P35561, P40310, Q00194, Q02280, S52072, U04246, U04270, U06745, U19907, U19908, U27558, U40947, U40990, U41104, U58730, Z49968, Z66519, Z70038, Z71261

External Links

PubMed source DOI: 10.1016/0028-3908(96)00126-8 View journal details

Analysis Services

Eight potassium channel families revealed by the C. elegans genome project.

Contact

WeChat Official Account