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PMID: 893665 Published · ppublish English Comparative Study Journal Article

Small airways in idiopathic pulmonary fibrosis. Comparison of morphologic and physiologic observations.

The Journal of clinical investigation ·Vol. 60 ·No. 3 ·1977-00-00 ·Pages 595-610

Fulmer JD, Roberts WC, von Gal ER, Crystal RG

Abstract

18 patients with idiopathic pulmonary fibrosis were studied to determine if they had morphologic evidence of small airways disease and if physiologic testing could predict morphologic findings. In the presence of normal airway function by standard physiologic studies (forced expiratory volume in 1 s/forced vital capacity and airway resistance by plethysmography), dynamic compliance, maximum expiratory flow-volume curves, and maximum flowstatic recoil curves were measured to detect physiologic alterations consistent with small airways abnormalities. These physiologic data were then compared with estimates of small airways diameter made in lung biopsy specimens.94% (17 of 18) of the patients had peribronchiolar fibrosis or peribronchiolar inflammation or bronchiolitis. 67% (12 of 18) had an overall estimate of small airways diameter of "narrowed," whereas 33% (6 of 18) had airways that overall were "not narrowed." 59% (10 of 17) had frequency-dependent dynamic compliance, 50% (9 of 18) had abnormal maximum expiratory flow-volume curves, and 39% (7 of 18) had abnormal maximum flow-static recoil curves. Comparisons between morphologic and physiologic data revealed a significant correlation between the results of dynamic compliance and the overall estimate of small airways diameter (P = 0.001), and the results of maximum flow-volume curves and the overall estimate of small airways diameter (P = 0.009); there was no significant correlation between the results of maximum flow-static recoil curves and the overall estimate of small airways diameter (P = 0.1). THE RESULTS OF THIS STUDY SUGGEST THAT: (a) idiopathic pulmonary fibrosis is a disease of small airways as well as alveoli; (b) dynamic compliance and the maximum expiratory flow-volume curve can predict the overall status of small airways diameter in idiopathic pulmonary fibrosis; and (c) whereas the maximum flowstatic recoil curve predicts the overall estimate of small airways diameter in most patients with this disease, it is the least sensitive of these three monitors of small airways.

MeSH Terms
Adult Aged Airway Resistance Female Humans Lung/pathology,physiopathology Lung Compliance Lung Volume Measurements Male Middle Aged Pulmonary Diffusing Capacity Pulmonary Fibrosis/pathology,physiopathology Pulmonary Ventilation Smoking
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fulmer J D
Roberts W C
von Gal E R
Crystal R G
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54 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI108811
Published
1977-00-00
Pages
595-610
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC372404
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI108811 PMC Full Text View journal details
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